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Mutations differentially affecting the coronavirus Mac1 ADP-ribose binding and hydrolysis activities indicate that it promotes multiple stages of the viral replication cycle

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.04.08.647734Source: DataRank Database

Mutations differentially affecting the coronavirus Mac1 ADP-ribose binding and hydrolysis activities indicate that it promotes multiple stages of the viral replication cycle is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2025). On theSindex it has a DataRank of 0.

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (4 grants)OA: greenTopics (32)IDs (PubMed, OpenAlex)

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Authors (10)

Anuradha Roy ORCID,Reem Khattabi,Catherine M. Kerr ORCID,Nancy Schwarting,Yousef M. Alhammad ORCID

Live enrichment

PubMed:19910364 OpenAlex:https://openalex.org/W4409289864

National Institutes of Health

Grant: 5P20GM113117-03

Chemical Biology of Infectious Disease

National Institutes of Health

Grant: 1K22AI134993-01

Investigating How ADP-ribosylation Impacts Innate Immunity During Coronavirus Infection

National Institutes of Health

Grant: 2T32GM132061-06A1

Graduate Training at the Biology-Chemistry Interface

National Institutes of Health

Grant: 1R35GM138029-01

Determining mechanisms of innate immune modulation by ADP-ribosylation

greenLicense: cc-by

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2025/04/09/2025.04.08.647734.full.pdf

repositoryhttps://doi.org/10.1101/2025.04.08.647734

https://doi.org/10.1128/jvi.00623-25

https://pubmed.ncbi.nlm.nih.gov/40736256

Fields of Study

PARP inhibition in cancer therapyCalcium signaling and nucleotide metabolismTryptophan and brain disorders0301 basic medicine03 medical and health sciences

Keywords

Replication (statistics)VirologyViral replicationCoronavirusRiboseBiologyMutationCoronavirus disease 2019 (COVID-19)Cell biologyGeneticsChemistryBiochemistryVirusMedicineEnzymeGeneAdenosine Diphosphate RiboseHydrolysisMacrophagesViral Nonstructural ProteinsVirus ReplicationGenome Replication and Regulation of Viral Gene ExpressionCell LineMiceAnimalsHumansProtein Binding