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PACT suppresses PKR activation through dsRNA binding and dimerization, and is a therapeutic target for triple-negative breast cancer

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.05.27.656288Source: DataRank Database

PACT suppresses PKR activation through dsRNA binding and dimerization, and is a therapeutic target for triple-negative breast cancer is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2025). On theSindex it has a DataRank of 0. It has been cited 1 time.

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (4 grants)OA: greenTopics (37)IDs (PubMed, OpenAlex)

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Authors (11)

Isabelle Juhler,Jackson R. Pierce ORCID,Holly E. Bohlin,H. Harper,David S. Onishile

Live enrichment

PubMed:40501907 OpenAlex:https://openalex.org/W4410777183

Grant: R00MD016946

Grant: P30CA023168

National Institutes of Health

Grant: 3P30CA023168-20S1

CORE--DNA ANALYSIS

National Institutes of Health

Grant: 5R00MD016946-05

Identifying determinants of ADAR-dependency in triple-negative breast cancer

greenLicense: https://www.biorxiv.org/about/FAQ#license

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2025/05/27/2025.05.27.656288.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2025.05.27.656288

repositoryhttps://doi.org/10.1101/2025.05.27.656288

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40501907

Fields of Study

RNA regulation and diseaseRNA Interference and Gene DeliveryRNA modifications and cancerBiologyMedicine0301 basic medicine03 medical and health sciences

Keywords

PactProtein kinase RTriple-negative breast cancerCancer researchBreast cancerRNA silencingGene silencingOncologyCancerChemistryVirologyInternal medicineMedicineRNA interferencePolitical scienceRNABiochemistryGeneAdenosine DeaminaseRNA-Binding ProteinsTriple Negative Breast NeoplasmsArticleGene Expression Regulation, NeoplasticeIF-2 KinaseCell Line, TumorHumansFemaleProtein MultimerizationRNA, Double-StrandedProtein Binding