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Discovery of Small Molecules and a Druggable Groove That Regulate DNA Binding and Release of the AP1 Transcription Factor ΔFOSB

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.10.21.683675Source: DataRank Database

Discovery of Small Molecules and a Druggable Groove That Regulate DNA Binding and Release of the AP1 Transcription Factor ΔFOSB is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2025). On theSindex it has a DataRank of 0. It has been cited 2 times.

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Open Access2 citations

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Enrichment:Funding (7 grants)OA: greenTopics (10)IDs (PubMed, OpenAlex)

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Accessible (1/2)

Open Access

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Authors (29)

Y.-I. Yim ORCID,Ashwani Kumar ORCID,Yi Li ORCID,Brandon W. Hughes ORCID,Corey P. St. Romain ORCID

Live enrichment

PubMed:41279307 OpenAlex:https://openalex.org/W4415483053

National Institutes of Health, National Institute on Drug Abuse

Grant: R01DA040621

National Institutes of Health, National Institute on Drug Abuse

Grant: R01DA040621-03S1

National Institutes of Health, National Institute on Drug Abuse

Grant: R01DA040621-07S1

National Institutes of Health, National Institute of Neurological Disorders and Stroke

Grant: R01NS085171

National Institutes of Health, National Institute on Aging

Grant: F30AG085919

Cancer Prevention and Research Institute of Texas

Grant: RP150578

NIDA NIH HHS

Grant: T32 DA053558

greenLicense: other-oa

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2025/10/23/2025.10.21.683675.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2025.10.21.683675

repositoryhttps://doi.org/10.1101/2025.10.21.683675

repositoryhttps://pubmed.ncbi.nlm.nih.gov/41279307

Fields of Study

Protein Degradation and InhibitorsClick Chemistry and ApplicationsEstrogen and related hormone effects

Keywords

AP-1 transcription factorDruggabilityTranscription factorSmall moleculeTranscription (linguistics)Binding siteDNA