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MYCN drives chemoresistance in small cell lung cancer while USP7 inhibition can restore chemosensitivity

Genes & Development(2020)10.1101/gad.340133.120Source: DataRank Database

MYCN drives chemoresistance in small cell lung cancer while USP7 inhibition can restore chemosensitivity is a research paper published in Genes & Development (2020). On theSindex it has a DataRank of 0. It has been cited 90 times.

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Open Access90 citations

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Enrichment:Funding (11 grants)OA: goldTopics (59)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (2)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (17)

Nan Wu ORCID,Huajia Zhang ORCID,Xiaoli Liu ORCID,Justin P. Norton ORCID,Yamini M. Ohol

Live enrichment

PubMed:32820040 PMC:PMC7462062 OpenAlex:https://openalex.org/W3080512596

National Institutes of Health

Grant: F30CA232475

NIH

Grant: U01CA235625

NIH

Grant: R01CA200547

NIH/National Cancer Institute Cancer Center

Grant: P30 CA015704

NCI NIH HHS

Grant: P50 CA228944

NIGMS NIH HHS

Grant: T32 GM007266

NIGMS NIH HHS

Grant: T32 GM007270

National Institutes of Health

Grant: 1F30CA232475-01

Role of MYC Family Members in Driving Chemoresistance in Small Cell Lung Cancer

National Institutes of Health

Grant: 5R01CA200547-04

Investigating CREBBP as a tumor suppressor in small cell lung cancer

National Institutes of Health

Grant: 3P30CA015704-42S2

Cancer Center Support Grant

National Institutes of Health

Grant: 5U01CA235625-02

Employing CRISPR inactivation screening and in vivo models towards improving treatments for SCLC

goldLicense: cc-by-nc

journalhttp://genesdev.cshlp.org/content/34/17-18/1210.full.pdf

publisherhttp://genesdev.cshlp.org/content/34/17-18/1210.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/gad.340133.120

journalhttps://doi.org/10.1101/gad.340133.120

repositoryhttps://pubmed.ncbi.nlm.nih.gov/32820040

Fields of Study

Lung Cancer Research StudiesPeptidase Inhibition and AnalysisCancer therapeutics and mechanisms0301 basic medicine0303 health sciences03 medical and health sciencesAnimalsCell Line, TumorDisease Models, AnimalDrug Resistance, NeoplasmEnzyme ActivationEnzyme InhibitorsHeterograftsHumansLung NeoplasmsMiceN-Myc Proto-Oncogene ProteinSmall Cell Lung CarcinomaUbiquitin-Specific Peptidase 7

MeSH Terms

N-Myc Proto-Oncogene ProteinUbiquitin-Specific Peptidase 7AnimalsDisease Models, AnimalEnzyme ActivationEnzyme InhibitorsHumansLung NeoplasmsDrug Resistance, NeoplasmCell Line, TumorMiceSmall Cell Lung CarcinomaHeterografts

Keywords

Cancer researchBiologyEtoposideCisplatinNeuroblastomaChemotherapyCell cultureGeneticsChemoresistanceSCLCMycnUsp7MyclN-Myc Proto-Oncogene ProteinLung NeoplasmsSmall Cell Lung CarcinomaEnzyme ActivationUbiquitin-Specific Peptidase 7Disease Models, AnimalMiceDrug Resistance, NeoplasmCell Line, TumorAnimalsHeterograftsHumansEnzyme InhibitorsResearch Paper

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

MYCN drives chemoresistance in small cell lung cancer while USP7 inhibition can restore chemosensitivity

FAIR Checklist

Authors (17)

Funding (11 grants)

Open Access

Topics

Annotations (Europe PMC)