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USP21 deubiquitinase elevates macropinocytosis to enable oncogenic KRAS bypass in pancreatic cancer

Genes & Development(2021)10.1101/gad.348787.121Source: DataRank Database

USP21 deubiquitinase elevates macropinocytosis to enable oncogenic KRAS bypass in pancreatic cancer is a research paper published in Genes & Development (2021). On theSindex it has a DataRank of 0. It has been cited 34 times.

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Open Access34 citations

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geo gen refseq

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Enrichment:Funding (9 grants)OA: goldTopics (38)IDs (PubMed, PMC, OpenAlex)Annotations (3)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (17)

Xingdi Ma ORCID,Zecheng Yang ORCID,Qiang Zhang ORCID,Chang‐Jiun Wu ORCID,Jun Li ORCID

Live enrichment

PubMed:34531315 PMC:PMC8494209 OpenAlex:https://openalex.org/W3199777965

NIH

Grant: R01 CA231349

NIH

Grant: P01 CA117969

NIH

Grant: R01 CA225955

National Institutes of Health

Grant: 1R01CA231349-01A1

Developing Novel Therapeutic Approaches Targeting Macrophages in GBM

National Institutes of Health

Grant: 3P30CA016672-41S4

Cancer Center Support (CORE) Grant

National Institutes of Health

Grant: 5P01CA117969-03

Core A: Molecular Imaging Core

National Institutes of Health

Grant: 5R01CA225955-02

Exploring Collateral Lethality for Development of Cancer Therapeutics

Hirshberg Foundation for Pancreatic Cancer Research

Seed Grant Program

goldLicense: cc-by-nc

journalhttps://doi.org/10.1101/gad.348787.121

GOLDhttps://doi.org/10.1101/gad.348787.121

publisherhttps://doi.org/10.1101/gad.348787.121

publisherhttps://syndication.highwire.org/content/doi/10.1101/gad.348787.121

repositoryhttps://pubmed.ncbi.nlm.nih.gov/34531315

Fields of Study

Ubiquitin and proteasome pathwaysCancer, Hypoxia, and MetabolismGenetics and Neurodevelopmental DisordersMedicineBiology0301 basic medicine03 medical and health sciences

MeSH Terms

Deubiquitinating EnzymesAnimalsPancreatic NeoplasmsProto-Oncogene Proteins p21(ras)Carcinoma, Pancreatic DuctalUbiquitin ThiolesteraseCell Line, TumorMice

Keywords

KRASBiologyCancer researchPancreatic cancerDeubiquitinating enzymeCancerColorectal cancerGeneGeneticsUbiquitinMacropinocytosisUsp21Targeted Therapy ResistanceMark3Pancreatic NeoplasmsProto-Oncogene Proteins p21(ras)Research CommunicationMiceDeubiquitinating EnzymesCell Line, TumorAnimalsUbiquitin ThiolesteraseCarcinoma, Pancreatic Ductal

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

USP21 deubiquitinase elevates macropinocytosis to enable oncogenic KRAS bypass in pancreatic cancer

FAIR Checklist

Authors (17)

Funding (9 grants)

Open Access

Topics

Annotations (Europe PMC)