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E3 ligase substrate adaptor SPOP fine-tunes the UPR of pancreatic β cells

Genes & Development(2024)10.1101/gad.352010.124Source: DataRank Database

E3 ligase substrate adaptor SPOP fine-tunes the UPR of pancreatic β cells is a research paper published in Genes & Development (2024). On theSindex it has a DataRank of 0.

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GEOGSE282084

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Enrichment:Funding (29 grants)OA: goldTopics (77)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

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Authors (17)

Matthew W. Haemmerle,Sabyasachi Sen ORCID,Andrea V. Rozo,Shristi Shrestha ORCID,Jeeyeon Cha ORCID

Live enrichment

PubMed:39797759 PMC:PMC11789638 OpenAlex:https://openalex.org/W4405893224

National Institutes of Health

Grant: DK121175

National Institutes of Health

Grant: DK122039

National Institutes of Health

Grant: DK135032

National Institutes of Health

Grant: DK127270

National Institutes of Health

Grant: DK105689

National Institutes of Health

Grant: DK019525

National Institutes of Health

Grant: 1R01DK138141

National Institutes of Health

Grant: 5U24DK097771

National Institutes of Health

Grant: K01DK129442

Diabetes Research Center at the University of Pennsylvania

Grant: P30DK19525

NIDDK NIH HHS

Grant: P30 DK019525

NIDDK NIH HHS

Grant: R01 DK121175

NIDDK NIH HHS

Grant: R01 DK135032

NIDDK NIH HHS

Grant: R01 DK105689

NIDDK NIH HHS

Grant: R01 DK082590

NIDDK NIH HHS

Grant: R01 DK138141

NIDDK NIH HHS

Grant: P30 DK116073

NIDDK NIH HHS

Grant: R01 DK122039

NIDDK NIH HHS

Grant: R01 DK127270

NIDDK NIH HHS

Grant: U24 DK097771

National Institutes of Health

Grant: 7K01DK129442-02

Circadian Control of Pancreatic Beta-cell Maturation

National Institutes of Health

Grant: 1R01DK127270-01A1

Structure dictates dynamic topology and function of pancreatic transcriptional regulators

National Institutes of Health

Grant: 5R01DK138141-02

Beta cell adaptation mechanisms during caloric restriction and ER stress

National Institutes of Health

Grant: 5P30DK019525-19

DIABETES ENDOCRINOLOGY RESEARCH CENTER

National Institutes of Health

Grant: 5R01DK121175-04

A stress inducible Pdx1 transcriptional complex governing beta cell survival

National Institutes of Health

Grant: 1R01DK135032-01

Functional interaction of transcriptional regulators in endocrine lineage specification

National Institutes of Health

Grant: 5R01DK122039-03

Role of the RNA-binding, polyC-binding proteins in pancreatic beta cells

National Institutes of Health

Grant: 5R01DK105689-04

Formation and maturation of endocrine pancreas progenitors

National Institutes of Health

Grant: 5U24DK097771-05

NIDDK Network Coordinating Unit

goldLicense: cc-by-nc

journalhttp://genesdev.cshlp.org/content/early/2024/12/26/gad.352010.124.full.pdf

publisherhttp://genesdev.cshlp.org/content/early/2024/12/26/gad.352010.124.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/gad.352010.124

journalhttps://doi.org/10.1101/gad.352010.124

repositoryhttps://pubmed.ncbi.nlm.nih.gov/39797759

Fields of Study

Endoplasmic Reticulum Stress and DiseasePancreatic function and diabetesAutophagy in Disease and TherapyMedicineBiology0301 basic medicine0303 health sciences03 medical and health sciencesAnimalsInsulin-Secreting CellsUnfolded Protein ResponseMiceRepressor ProteinsNuclear ProteinsX-Box Binding Protein 1Mice, KnockoutProtein Serine-Threonine KinasesSignal TransductionInsulinEndoplasmic Reticulum StressInsulin SecretionGlucoseUbiquitin-Protein LigasesEndoribonucleasesUbiquitin-Protein Ligase Complexes

MeSH Terms

X-Box Binding Protein 1Insulin SecretionAnimalsEndoribonucleasesGlucoseHumansInsulinNuclear ProteinsRepressor ProteinsTranscription FactorsSignal TransductionProtein Serine-Threonine KinasesMice, KnockoutUbiquitin-Protein Ligase ComplexesUbiquitin-Protein LigasesInsulin-Secreting CellsMiceUnfolded Protein ResponseProteolysisEndoplasmic Reticulum Stress

Keywords

Ubiquitin ligaseBiologyXBP1Unfolded protein responseSignal transducing adaptor proteinCell biologyDDB1CullinUbiquitinEndoplasmic reticulumSignal transductionBiochemistryGeneProteasomeDiabetesβ cellsX-Box Binding Protein 1Mice, KnockoutUbiquitin-Protein LigasesNuclear ProteinsUbiquitin-Protein Ligase ComplexesProtein Serine-Threonine KinasesEndoplasmic Reticulum StressResearch PapersRepressor ProteinsMiceGlucoseInsulin-Secreting CellsInsulin SecretionEndoribonucleasesAnimalsInsulin

Sustainable Development Goals

SDG 0: Good health and well-being

E3 ligase substrate adaptor SPOP fine-tunes the UPR of pancreatic β cells

FAIR Checklist

Authors (17)

Funding (29 grants)

Open Access

Topics

Annotations (Europe PMC)