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Short‐term starvation activates AMPK and restores mitochondrial inorganic polyphosphate, but fails to reverse associated neuronal senescence

Aging Cell(2024)10.1111/acel.14289Source: DataRank Database

Short‐term starvation activates AMPK and restores mitochondrial inorganic polyphosphate, but fails to reverse associated neuronal senescence is a research paper published in Aging Cell (2024). On theSindex it has a DataRank of 0. It has been cited 8 times.

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Enrichment:Funding (11 grants)OA: goldTopics (83)IDs (PubMed, PMC)

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Authors (15)

Renata Torres da Costa ORCID,Lavinia Boccia,Sheida Kavehmoghaddam,Bryan Ramirez,Małgorzata Tokarska-Schlattner ORCID

Live enrichment

PubMed:39102875 PMC:PMC11561667

National Institutes of Health

Grant: 1R01AG079877

National Institutes of Health

Grant: 1R01DK13339

Rutgers, The State University of New Jersey

Grant: Start‐Upfunds

NIDDK NIH HHS

Grant: R01 DK133399

Rutgers University

Grant: Start-Upfunds

NIA NIH HHS

Grant: R01 AG079877

NIGMS NIH HHS

Grant: R35 GM150799

National Institutes of Health

Grant: 5R01DK013339-18

METAL COMPLEXES RELATED TO VITAMIN B12

National Institutes of Health

Grant: 5R01AG079877-03

Deconstruction of a Hypothalamic Exercise-responsive Circuit for Neuroprotection

University of Genoa

Università degli Studi di Genova

goldLicense: cc-by

publisherhttps://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/acel.14289

publisherhttps://onlinelibrary.wiley.com/doi/pdf/10.1111/acel.14289

repositoryhttps://hal.univ-grenoble-alpes.fr/hal-04920763/document

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC11561667/pdf/ACEL-23-e14289.pdf

repositoryhttps://hdl.handle.net/11567/1231795

Fields of Study

0301 basic medicine0303 health sciences03 medical and health sciences

MeSH Terms

NeuronsMitochondriaAnimalsMice, Inbred C57BLHumansMicePolyphosphatesMaleAMP-Activated Protein KinasesCellular Senescence

Keywords

MitochondriaMetabolismSenescencefastingDietary RestrictionPolypInorganic PolyphosphateADPMaleCarbonyl cyanide m-chlorophenylhydrazone CREBcAMP Response Element-Binding Protein CtrlEndopolyphosphateses PPXcells expressing the PPX enzyme in their mitochondria NIHTris(hydroxymethyl)-1,3-propanediol hydrochloride WtAMP-Activated Protein KinasesElectron transfer chain FBSpDrp1Oxygen consumption rate OXPHOSMiceWild-typePhospho-AMPK (Thr172) pAMPKPolyphosphatesInstitutional animal care and use committee IPAPhosphatebuffered saline PCAsHank's Balanced salt solution HPLCCellular Senescencedietary restriction; fasting; inorganic polyphosphate; metabolism; mitochondria; polyP; senescenceNeuronsEthylenediaminetetraacetic acid EGTAInorganic polyphosphate PPNLactate deshydrogenase MgCl2The National Institutes of Health OCRStandard error of the mean STSPolyvinylidene fluoride RADimethyl sulfoxide Drp1Research Article570Phospho-CREB (Ser133)Adenosine monophosphate AMPKPotassium chloride LC3High-performance liquid chromatography IACUCAMP-activated protein kinase ATPDulbecco's Modified Eagle medium DMSO610Differentiated SH-SY5Y cells EDTAMagnesium chloride MitoPPXAdenosine triphosphate BSAPhospho-AMPK (Thr172) PBSExopolyphosphatases PVDFFetal bovine serum HBSSControl DAPIIngenuity Pathway Analysis K2CO3AnimalsHumansEthylene glycol-bis(2aminoethylether)-N,N,N′,N′-tetraacetic acid ETC4′,6-diamidino-2-phenylindole DMEMPhenylmethylsulfonyl fluoride PolyPReactive oxygen species SEMShort-term starvation THBMicrotubuleassociate protein 1A/1B-ligth chain 3 LDHBovine serum albumin CCCPPrincipal component analysis pCREBDynamin-related protein 1 dSH-SY5YAdenosine diphosphate AMPMice, Inbred C57BLRetinoic acid ROSTissue homogenizing buffer Tris-HClPotassium carbonate KClPhospho-Drp1 (Ser616) PMSFOxidative phosphorylation pAMPK