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Binding kinetics, bias, receptor internalization and effects on insulin secretion in vitro and in vivo of a novel GLP ‐ 1R / GIPR dual agonist, HISHS ‐2001

Diabetes Obesity and Metabolism(2025)10.1111/dom.16652Source: DataRank Database

Binding kinetics, bias, receptor internalization and effects on insulin secretion in vitro and in vivo of a novel GLP ‐ 1R / GIPR dual agonist, HISHS ‐2001 is a research paper published in Diabetes Obesity and Metabolism (2025). On theSindex it has a DataRank of 0. It has been cited 1 time.

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Open Access1 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (17 grants)Impact (FWCI 0.66)OA: hybridTopics (42)IDs (PubMed, PMC, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (12)

Ben Jones ORCID,Gaëlle Carrat ORCID,Zenouska Ramchunder ORCID,Piero Marchetti ORCID,Isabelle Leclerc ORCID

Live enrichment

PubMed:40831316 PMC:PMC12409219 OpenAlex:https://openalex.org/W4413358799

Division of Diabetes, Endocrinology, and Metabolic Diseases

Grant: R01DK135268

Institute of Nutrition, Metabolism and Diabetes

Grant: CIHR‐IRSC TDP‐186358

Canada Foundation for Innovation

Grant: CFI 42649

Medical Research Council

Grant: MR/R022259/1

Medical Research Council

Grant: MR/X021467/1

Wellcome Trust

Grant: 301619/Z/23/Z

Wellcome Trust

Grant: WT212625/Z/18/Z

Diabetes UK

Grant: BDA 16/0005485

Breaktrough Type 1 Diabetes

Grant: 4-SRA-2023-1182-S-N

Diabetes UK

Grant: 16/0005485

Institute of Nutrition, Metabolism and Diabetes

Grant: CIHR-IRSC TDP-186358

CIHR-JDRF Team

Grant: JDRF 4-SRA-2023-1182-S-N

Society for Endocrinology

Wellcome Trust

CRCHUM

Sun Pharmaceutical Industries

Lilly Research Award Program

FWCI

0.66

Citation Percentile

0.7%

Citation Trend

2025

hybridLicense: cc-by

journalhttps://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/dom.16652

publisherhttps://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/dom.16652

publisherhttps://dom-pubs.pericles-prod.literatumonline.com/doi/pdf/10.1111/dom.16652

publisherhttps://dom-pubs.pericles-prod.literatumonline.com/doi/full-xml/10.1111/dom.16652

journalhttps://doi.org/10.1111/dom.16652

Fields of Study

Diabetes Treatment and ManagementPancreatic function and diabetesRegulation of Appetite and Obesity

MeSH Terms

Glucagon-Like Peptide-1 ReceptorInsulin SecretionGlucagon-Like Peptide-1 Receptor AgonistsAnimalsDiabetes Mellitus, Type 2HumansHypoglycemic AgentsInsulinIslets of LangerhansKineticsMaleMice, Inbred C57BLProtein BindingReceptors, Gastrointestinal HormoneMice

Keywords

ReceptorIncretinAgonistInternalizationInternal medicineEndocrinologyG protein-coupled receptorInsulinIn vivoDownregulation and upregulationGlucagon-like peptide-1MedicineGlucagon-like peptide 1 receptorType 2 diabetesPharmacologyDiabetes mellitusChemistryBiologyBiochemistryinsulin secretionBeta Cell FunctionAntidiabetic DrugAntiobesity DrugGlp‐1 Analogue

Sustainable Development Goals

SDG 0: Good health and well-being