Reversibly acetylated lysine residues play important roles in the enzymatic activity of <i><scp>E</scp>scherichia coli <scp>N</scp></i>‐hydroxyarylamine <i><scp>O</scp></i>‐acetyltransferase is a research paper published in The FEBS Journal (2013). On theSindex it has a DataRank of 1.4. It has been cited 34 times, with 30 citing works in its 1-hop citation network.
CobB is a bacterial NAD+‐dependent protein deacetylase. Although progress has been made in functional studies of this protein in recent years, its substrates and biological functions are still largely unclear. Using proteome microarray technology, potential substrates of Escherichia coli CobB were screened and nine proteins were identified, including N‐hydroxyarylamine O‐acetyltransferase (NhoA). In vitro acetylation/deacetylation of NhoA was verified by western blotting and mass spectrometry, and two acetylated lysine residues were identified. Site‐specific mutagenesis experiments showed that mutation of each acetylated lysine decreased the acetylation level of NhoA in vitro. Further analysis showed that variant NhoA proteins carrying substitutions at the two acetylated lysine residues are involved in both the O‐acetyltransferase and N‐acetyltransferase activity of NhoA. Structural analyses were also performed to explore the effects of the acetylated lysine residues on the activity of NhoA. These results suggest that reversible acetylation may play a role in the activity of Escherichia coli NhoA.
FAIR checklist signals are shown for context only and do not affect DataRank scoring.
Base Score Contribution
0.533
From this paper's citation signal
Citation Network Contribution
0.843
From 26 citing papers with measurable signal
Ranked by citation count — the same ordering the engine uses when summing log1p(Cq) over citers.
DataRank blends this paper's own citation count with the influence of the papers that cite it. Here, roughly 39% comes from its base citations and 61% from the citation network (26 citing papers contributed measurable signal).
Citers are pulled from OpenAlex sorted by cited_by_count:descand capped per paper, so when the cap binds we keep the highest-signal references and the score is reproducible across reruns.
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