Native Human Serum Amyloid P Component is a Single Pentamer is a research paper published in Scandinavian Journal of Immunology (1995). On theSindex it has a DataRank of 1.4. It has been cited 26 times, with 21 citing works in its 1-hop citation network. Its calibrated FAIR score is 49/100.
Serum amyloid P component (SAP) and C‐reactive protein (CRP) are members of the pentraxin protein family. SAP is the precursor protein to amyloid P component present in all forms of amyloidosis. The prevailing notion is that SAP in circulation has the form of a double pentameric molecule (decamer) whereas CRP is a single pentameric molecule.We have investigated by gel permeation chromatography the Mr of SAP in freshly collected human serum and of SAP purified by carbohydrate affinity chromatography and anion exchange chromatography. SAP was monitored by quantitative immunoelectrophoresis and ELISA. and SAP peak fractions were analysed by use of SDS‐PAGE, Western blotting, and electron microscopy. The results indicate that native SAP circulates as a single pentamer, a part of which forms complexes with C4b‐binding protein. The properties of SAP changed during purification as indicated by rocket immuno‐electrophoresis and electron microscopy. Thus, electron micrographs of purified SAP showed a predominance of decamers. However, the decamer form of SAP reversed to single pentamers when purified SAP was incorporated into SAP‐depleted serum.
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Calibrated FAIR score — a parallel quality metric, independent of the DataRank citation score. See the full evaluation →
Base Score Contribution
0.494
From this paper's citation signal
Citation Network Contribution
0.898
From 19 citing papers with measurable signal
Ranked by citation count — the same ordering the engine uses when summing log1p(Cq) over citers.
DataRank blends this paper's own citation count with the influence of the papers that cite it. Here, roughly 36% comes from its base citations and 64% from the citation network (19 citing papers contributed measurable signal).
Citers are pulled from OpenAlex sorted by cited_by_count:descand capped per paper, so when the cap binds we keep the highest-signal references and the score is reproducible across reruns.
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