CARBOXYMETHYLATION OF SULPHYDRYL GROUPS IN PROTEOLIPIDS<sup>1</sup> is a research paper published in Journal of Neurochemistry (1969). On theSindex it has a DataRank of 3.6. It has been cited 33 times, with 32 citing works in its 1-hop citation network. Its calibrated FAIR score is 49/100.
Abstract—(1) The sulphydryl groups of brain white matter proteolipids were studied by alkylation with iodoacetic acid and iodoacetamide in an organic solvent medium. To make sterically hindered sulphydryl groups available, the reaction was also carried out in the presence of sodium dodecyl sulphate.(2) In all cases, iodoacetamide was a better alkylating agent than was iodoacetic acid.(3) Only minimal alkylation of crude white matter proteolipids was obtained in the absence of detergent; addition of sodium dodecyl sulphate increased the availablity of SH groups.(4) Purified proteolipids prepared by column chromatography were alkylated to a lesser degree than were crude proteolipids.(5) Prior reduction with mercaptoethanol resulted in the quantitative conversion of cysteine to S‐carboxymethylcysteine with either alkylating agent and in both preparations.(6) The possibility of a conformational difference between the protein in the crude and purified preparations is discussed.
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Calibrated FAIR score — a parallel quality metric, independent of the DataRank citation score. See the full evaluation →
Base Score Contribution
0.529
From this paper's citation signal
Citation Network Contribution
3.1
From 31 citing papers with measurable signal
Ranked by citation count — the same ordering the engine uses when summing log1p(Cq) over citers.
DataRank blends this paper's own citation count with the influence of the papers that cite it. Here, roughly 15% comes from its base citations and 85% from the citation network (31 citing papers contributed measurable signal).
Citers are pulled from OpenAlex sorted by cited_by_count:descand capped per paper, so when the cap binds we keep the highest-signal references and the score is reproducible across reruns.
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