Roles of base excision repair subpathways in correcting oxidized abasic sites in DNA is a research paper published in The FEBS Journal (2006). On theSindex it has a DataRank of 6.0. It has been cited 152 times, with 146 citing works in its 1-hop citation network.
Base excision DNA repair (BER) is fundamentally important in handling diverse lesions produced as a result of the intrinsic instability of DNA or by various endogenous and exogenous reactive species. Defects in the BER process have been associated with cancer susceptibility and neurodegenerative disorders. BER funnels diverse base lesions into a common intermediate, apurinic/apyrimidinic (AP) sites. The repair of AP sites is initiated by the major human AP endonuclease, Ape1, or by AP lyase activities associated with some DNA glycosylases. Subsequent steps follow either of two distinct BER subpathways distinguished by repair DNA synthesis of either a single nucleotide (short‐patch BER) or multiple nucleotides (long‐patch BER). As the major repair mode for regular AP sites, the short‐patch BER pathway removes the incised AP lesion, a 5′‐deoxyribose‐5‐phosphate moiety, and replaces a single nucleotide using DNA polymerase (Polβ). However, short‐patch BER may have difficulty handling some types of lesions, as shown for the C1′‐oxidized abasic residue, 2‐deoxyribonolactone (dL). Recent work indicates that dL is processed efficiently by Ape1, but that short‐patch BER is derailed by the formation of stable covalent crosslinks between Ape1‐incised dL and Polβ. The long‐patch BER subpathway effectively removes dL and thereby prevents the formation of DNA–protein crosslinks. In coping with dL, the cellular choice of BER subpathway may either completely repair the lesion, or complicate the repair process by forming a protein–DNA crosslink.
FAIR checklist signals are shown for context only and do not affect DataRank scoring.
Base Score Contribution
0.755
From this paper's citation signal
Citation Network Contribution
5.2
From 129 citing papers with measurable signal
Ranked by citation count — the same ordering the engine uses when summing log1p(Cq) over citers.
DataRank blends this paper's own citation count with the influence of the papers that cite it. Here, roughly 13% comes from its base citations and 87% from the citation network (129 citing papers contributed measurable signal).
Citers are pulled from OpenAlex sorted by cited_by_count:descand capped per paper, so when the cap binds we keep the highest-signal references and the score is reproducible across reruns.
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