Biochemical analysis of the human EVL domains in homologous recombination is a research paper published in The FEBS Journal (2009). On theSindex it has a DataRank of 0.208. It has been cited 3 times, with 1 citing works in its 1-hop citation network.
EVL is a member of the ENA/VASP family, which is involved in actin‐remodeling processes. Previously, we reported that human EVL directly interacts with RAD51, which is an essential protein in the homologous recombinational repair of DNA double‐strand breaks, and stimulates RAD51‐mediated recombination reactions in vitro. To identify the EVL domain required for the recombination function, we purified the EVL fragments EVL(1–221) and EVL(222–418), which contain the EVH1 and Pro‐rich domains and the EVH2 domain, respectively. We found that EVL(222–418) possesses DNA‐binding and RAD51‐binding activities, and also stimulates RAD51‐mediated homologous pairing. In contrast, EVL(1–221) did not exhibit any of these activities. Therefore, the EVH2 domain, which is highly conserved among the ENA/VASP family proteins, may be responsible for the recombination function of EVL.Structured digital abstract MINT‐7239394: EVL (uniprotkb:Q9UI08) binds (MI:0407) to RAD51 (uniprotkb:Q06609) by pull down (MI:0096)
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Base Score Contribution
0.208
From this paper's citation signal
Citation Network Contribution
0
From 0 citing papers with measurable signal
This paper's DataRank is currently driven only by its base citation score. None of the citing papers had measurable citation signal.
Learn more about DataRank methodology →DataRank blends this paper's own citation count with the influence of the papers that cite it. Here, roughly 100% comes from its base citations and 0% from the citation network.
Citers are pulled from OpenAlex sorted by cited_by_count:descand capped per paper, so when the cap binds we keep the highest-signal references and the score is reproducible across reruns.