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Beneficial Effects of Soluble Guanylyl Cyclase Stimulation and Activation in Sickle Cell Disease Are Amplified by Hydroxyurea: In Vitro and In Vivo Studies

Journal of Pharmacology and Experimental Therapeutics(2020)10.1124/jpet.119.264606Source: DataRank Database

Beneficial Effects of Soluble Guanylyl Cyclase Stimulation and Activation in Sickle Cell Disease Are Amplified by Hydroxyurea: In Vitro and In Vivo Studies is a research paper published in Journal of Pharmacology and Experimental Therapeutics (2020). On theSindex it has a DataRank of 0. It has been cited 15 times.

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Open Access15 citations

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Enrichment:Funding (7 grants)OA: hybridTopics (44)IDs (PubMed, PMC)Annotations (1)SDGs (1)

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Authors (18)

Hanan Chweih ORCID,Carolina Lanaro ORCID,Camila Bononi Almeida ORCID,Pâmela L. Brito ORCID,Érica M.F. Gotardo ORCID

Live enrichment

PubMed:32631869 PMC:PMC7445859

NIDDK NIH HHS

Grant: R01 DK112976

NHLBI NIH HHS

Grant: R01 HL069438

NIDDK NIH HHS

Grant: R01 DK056638

NIDDK NIH HHS

Grant: U01 DK116312

National Institutes of Health

Grant: 5R01DK056638-05

ADHESION PATHWAYS OF BLOOD/ENDOTHELIAL PROGENITORS

National Institutes of Health

Grant: 5R01DK112976-05

Mechanisms regulating the aging of HSC niches

National Institutes of Health

Grant: 5R01HL069438-20

In vivo mechanisms mediating sickle cell vaso-occlusion

hybridLicense: CC BY

publisherhttps://api.elsevier.com/content/article/PII:S0022356524258316?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0022356524258316?httpAccept=text/plain

publisherhttps://syndication.highwire.org/content/doi/10.1124/jpet.119.264606

Unpaywallhttps://jpet.aspetjournals.org/content/jpet/374/3/469.full.pdf

Europe_PMChttps://europepmc.org/articles/PMC7445859

Fields of Study

0301 basic medicine0303 health sciences03 medical and health sciences

MeSH Terms

Cell Line, TumorK562 CellsErythroid CellsAnimalsMice, Inbred C57BLHumansMiceVascular DiseasesAnemia, Sickle CellDisease Models, AnimalBenzoatesBiphenyl CompoundsHydrocarbons, FluorinatedHydroxyureaPyrazolesPyridinesFetal HemoglobinVasodilator AgentsMaleSoluble Guanylyl Cyclase

Keywords

MaleHydrocarbons, FluorinatedPyridinesVasodilator AgentsBiphenyl CompoundsAnemia, Sickle CellBenzoatesMice, Inbred C57BLDrug Discovery and Translational MedicineDisease Models, AnimalMiceSoluble Guanylyl CyclaseErythroid CellsCell Line, TumorAnimalsHumansHydroxyureaPyrazolesVascular DiseasesK562 CellsFetal Hemoglobin

Sustainable Development Goals

SDG 3: 3. Good health

Beneficial Effects of Soluble Guanylyl Cyclase Stimulation and Activation in Sickle Cell Disease Are Amplified by Hydroxyurea: In Vitro and In Vivo Studies

FAIR Checklist

Authors (18)

Funding (7 grants)

Open Access

Topics

Annotations (Europe PMC)