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Ketamine Produces Antidepressant Effects by Inhibiting Histone Deacetylases and Upregulating Hippocampal Brain-Derived Neurotrophic Factor Levels in a Diisopropyl Fluorophosphate–Based Rat Model of Gulf War Illness

Journal of Pharmacology and Experimental Therapeutics(2023)10.1124/jpet.123.001824Source: DataRank Database

Ketamine Produces Antidepressant Effects by Inhibiting Histone Deacetylases and Upregulating Hippocampal Brain-Derived Neurotrophic Factor Levels in a Diisopropyl Fluorophosphate–Based Rat Model of Gulf War Illness is a research paper published in Journal of Pharmacology and Experimental Therapeutics (2023). On theSindex it has a DataRank of 0. It has been cited 10 times.

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Open Access10 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (2 grants)Impact (FWCI 0.81)OA: bronzeTopics (65)IDs (PubMed, PMC, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (6)

Dalia Al Saeedy ORCID,Fay M. Jahr,Elisa Hawkins,Joseph L. McClay ORCID,Laxmikant S. Deshpande ORCID

Live enrichment

PubMed:37863487 PMC:PMC10801753 OpenAlex:https://openalex.org/W4387822798

NCI NIH HHS

Grant: P30 CA016059

National Institutes of Health

Grant: 4P30CA016059-35

Massey Cancer Center Support Grant

FWCI

0.81

Citation Percentile

0.7%

Citation Trend

2023

2024

2025

2026

bronzeLicense: CC BY NC

journalhttps://jpet.aspetjournals.org/content/jpet/early/2023/10/20/jpet.123.001824.full.pdf

publisherhttps://jpet.aspetjournals.org/content/jpet/early/2023/10/20/jpet.123.001824.full.pdf

publisherhttps://api.elsevier.com/content/article/PII:S0022356524171959?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0022356524171959?httpAccept=text/plain

publisherhttps://syndication.highwire.org/content/doi/10.1124/jpet.123.001824

Fields of Study

Tryptophan and brain disordersTreatment of Major DepressionAnesthesia and Neurotoxicity Research03 medical and health sciences0302 clinical medicineRatsMaleAnimalsRats, Sprague-DawleyKetamineBrain-Derived Neurotrophic FactorGulf WarPersian Gulf SyndromeHistonesHippocampusAntidepressive AgentsFluoridesPhosphates

MeSH Terms

AnimalsAntidepressive AgentsFluoridesHippocampusHistonesKetamineMalePhosphatesRats, Sprague-DawleyPersian Gulf SyndromeBrain-Derived Neurotrophic FactorGulf WarRats

Keywords

Downregulation and upregulationChromatin immunoprecipitationBrain-derived neurotrophic factorNeurotrophic factorsHistone deacetylaseEpigeneticsAntidepressantDendritic spineHistoneHistone acetyltransferaseEndocrinologyPharmacologyMedicineHistone methylationHippocampal formationInternal medicineChemistryHippocampusGene expressionBiochemistryDNA methylationReceptorMaleSpecial Section on Medical CountermeasuresAntidepressive AgentsRatsGulf WarPhosphatesRats, Sprague-DawleyHistonesFluoridesAnimalsKetaminePersian Gulf Syndrome

Sustainable Development Goals

SDG 0: Life below water