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A Point Mutation at C151 of Keap1 of Mice Abrogates NRF2 Signaling, Cytoprotection in Vitro, and Hepatoprotection in Vivo by Bardoxolone Methyl (CDDO-Me)

Molecular Pharmacology(2023)10.1124/molpharm.123.000671Source: DataRank Database

A Point Mutation at C151 of Keap1 of Mice Abrogates NRF2 Signaling, Cytoprotection in Vitro, and Hepatoprotection in Vivo by Bardoxolone Methyl (CDDO-Me) is a research paper published in Molecular Pharmacology (2023). On theSindex it has a DataRank of 0. It has been cited 33 times.

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Open Access33 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (4 grants)Impact (FWCI 3.05)OA: hybridTopics (53)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (8)

Yoko Yagishita,Tanvi Joshi ORCID,Nobunao Wakabayashi ORCID,Harini Srinivasan ORCID,Takafumi Suzuki ORCID

Live enrichment

PubMed:37188495 PMC:PMC10353147 OpenAlex:https://openalex.org/W4376610098

NCI NIH HHS

Grant: R35 CA197222

NCI NIH HHS

Grant: P30 CA015704

National Institutes of Health

Grant: 5R35CA197222-03

Targeting Nrf2 for Cancer Chemoprevention

National Institutes of Health

Grant: 3P30CA015704-42S2

Cancer Center Support Grant

FWCI

3.05

Citation Percentile

0.9%

Citation Trend

2023

2024

2025

2026

hybridLicense: cc-by

journalhttps://molpharm.aspetjournals.org/content/molpharm/early/2023/05/15/molpharm.123.000671.full.pdf

HYBRIDhttps://molpharm.aspetjournals.org/content/molpharm/early/2023/05/15/molpharm.123.000671.full.pdf

publisherhttps://molpharm.aspetjournals.org/content/molpharm/early/2023/05/15/molpharm.123.000671.full.pdf

publisherhttps://api.elsevier.com/content/article/PII:S0026895X2400035X?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0026895X2400035X?httpAccept=text/plain

Fields of Study

Genomics, phytochemicals, and oxidative stressGlutathione Transferases and PolymorphismsMedicineBiology0301 basic medicine03 medical and health sciencesMiceAnimalsKelch-Like ECH-Associated Protein 1NF-E2-Related Factor 2Point MutationCytoprotectionCysteineSignal TransductionOleanolic AcidMice, KnockoutHepatitis

MeSH Terms

Kelch-Like ECH-Associated Protein 1AnimalsCysteineHepatitisOleanolic AcidSignal TransductionPoint MutationMice, KnockoutCytoprotectionNF-E2-Related Factor 2Mice

Keywords

BiologyKEAP1HepatoprotectionKnockout mouseGCLMMutantHMOX1PharmacologyGCLCBiochemistryHemeHeme oxygenaseGeneMice, KnockoutKelch-Like ECH-Associated Protein 1NF-E2-Related Factor 2ArticlesHepatitisMiceCytoprotectionAnimalsPoint MutationCysteineOleanolic AcidSignal Transduction

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

A Point Mutation at C151 of Keap1 of Mice Abrogates NRF2 Signaling, Cytoprotection in Vitro, and Hepatoprotection in Vivo by Bardoxolone Methyl (CDDO-Me)

FAIR Checklist

Authors (8)

Funding (4 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)