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Cathepsin B Gene Knockout Improves Behavioral Deficits and Reduces Pathology in Models of Neurologic Disorders

Pharmacological Reviews(2022)10.1124/pharmrev.121.000527Source: DataRank Database

Cathepsin B Gene Knockout Improves Behavioral Deficits and Reduces Pathology in Models of Neurologic Disorders is a research paper published in Pharmacological Reviews (2022). On theSindex it has a DataRank of 0. It has been cited 96 times.

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Open Access96 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (6 grants)OA: hybridTopics (53)IDs (PubMed)SDGs (1)

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Authors (7)

Thomas Reinheckel ORCID,Junjun Ni ORCID,Zhou Wu ORCID,Mark S. Kindy ORCID,Christoph Peters ORCID

Live enrichment

PubMed:35710131

National Institutes of Health

Grant: 5R01NS109075-04

Development of Molecular Probe Inhibitors of Pathogenic, Cytosolic Cathespin B in Traumatic Brain Injury and Alzheimers Disease Neurodegeneration

National Institutes of Health

Grant: 3R41NS110147-01S2

Administrative Supplement to restore fee funds

Deutsche Forschungsgemeinschaft

Grant: 39236281/EXC 294

BIOSS Centre for Biological Signalling Studies - from Analysis to Synthesis

BLRD VA

Grant: IK6 BX005239

NINDS NIH HHS

Grant: R01 NS109075

NINDS NIH HHS

Grant: R41 NS110147

hybridLicense: cc-by

publisherhttps://pharmrev.aspetjournals.org/content/pharmrev/74/3/600.full.pdf

publisherhttps://api.elsevier.com/content/article/PII:S0031699724007282?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0031699724007282?httpAccept=text/plain

publisherhttps://syndication.highwire.org/content/doi/10.1124/pharmrev.121.000527

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/9553114

Fields of Study

0301 basic medicine03 medical and health sciences0303 health sciencesAlzheimer DiseaseAnimalsCathepsin BDisease Models, AnimalGene Knockout TechniquesHumansMiceMice, KnockoutMice, Transgenic

MeSH Terms

Alzheimer DiseaseAnimalsCathepsin BDisease Models, AnimalGene Knockout TechniquesHumansMiceMice, KnockoutMice, Transgenic

Keywords

AgingKnockout610Mice, TransgenicNeurodegenerativeAlzheimer's DiseaseTransgenicCathepsin BGene Knockout TechniquesMiceAlzheimer DiseaseAcquired Cognitive ImpairmentGenetics2.1 Biological and endogenous factorsAnimalsHumansPharmacology & PharmacyAetiologyMice, KnockoutBiomedical and Clinical SciencesAnimalNeurosciencesAlzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD)Pharmacology and Pharmaceutical SciencesBrain DisordersDisease Models, AnimalGood Health and Well Being5.1 PharmaceuticalsNeurologicalDisease ModelsDementiaDevelopment of treatments and therapeutic interventions

Sustainable Development Goals

SDG 3: 3. Good health