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Single-cell transcriptomics identifies multiple pathways underlying antitumor function of TCR- and CD8αβ-engineered human CD4 + T cells

Science Advances(2020)10.1126/sciadv.aaz7809Source: DataRank Database

Single-cell transcriptomics identifies multiple pathways underlying antitumor function of TCR- and CD8αβ-engineered human CD4 + T cells is a research paper published in Science Advances (2020). On theSindex it has a DataRank of 0. It has been cited 34 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access34 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (16 grants)Impact (FWCI 1.82)OA: goldTopics (52)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (18)

Gagan Bajwa ORCID,Benoît M. Carrères ORCID,Elisabeth Hoyer ORCID,Isabelle Gruber ORCID,Melisa Martinez-Paniagua ORCID

Live enrichment

PubMed:32923584 PMC:PMC7455496 OpenAlex:https://openalex.org/W3039855973

National Institutes of Health

Grant: R01CA174385

National Cancer Institute

Grant: P30CA125123

Cancer Prevention and Research Institute of Texas

Grant: RP160345

Leukemia and Lymphoma Society

Grant: 6490-16

Swiss National Science Foundation

Grant: 31003A_182470

Swiss National Science Foundation

Grant: 31003A_173156

Krebsforschung Schweiz

Grant: KFS-4542-08-2018-R

European Research Council

Grant: 802773

Integration and adaptation of impaired mitochondrial fitness in orchestrating T cell dysfunction in the tumor microenvironment

Swiss National Science Foundation

Grant: 173156

Computational biology analyses to characterize immune cell infiltrations in the tumor micro-environment using bulk and single-cell gene expression data

Swiss National Science Foundation

Grant: 182470

Role of metabolic crosstalk between immune and cancer cells in restricting host anti-tumor immunity and its implications in cancer immunotherapy

National Institutes of Health

Grant: 3P30CA125123-09S3

Baylor College of Medicine Cancer Center

National Science Foundation

Grant: 1705464

Biomanufacturing next generation T cells

National Institutes of Health

Grant: 5R01CA174385-04

Quantitative single-cell biomarkers of T-cells to optimize tumor immunotherapy

National Institutes of Health

Grant: 5R01LM013039-02

HealthyMe/MiSalud Smartphone Application: Identifying Mechanisms to Engage African Americans and Hispanics in Personal Health Libraries

National Institutes of Health

Grant: 1R43CA180466-01A1

Prostate Cancer Detection Through Urine Headspace Analysis Using Colorimetric Sen

Swiss Government Excellence Scholarship

FWCI

1.82

Citation Percentile

0.9%

Citation Trend

2020

2021

2022

2023

2024

2025

2026

goldLicense: cc-by-nc

journalhttps://advances.sciencemag.org/content/advances/6/27/eaaz7809.full.pdf

publisherhttps://advances.sciencemag.org/content/advances/6/27/eaaz7809.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1126/sciadv.aaz7809

publisherhttps://www.science.org/doi/pdf/10.1126/sciadv.aaz7809

journalhttps://doi.org/10.1126/sciadv.aaz7809

Fields of Study

CAR-T cell therapy researchImmune Cell Function and InteractionT-cell and B-cell Immunology0301 basic medicine03 medical and health sciences0302 clinical medicineAnimalsCD4-Positive T-LymphocytesCD8 AntigensCD8-Positive T-LymphocytesHumansMiceNeoplasmsReceptors, Antigen, T-CellTranscriptome

MeSH Terms

AnimalsHumansNeoplasmsReceptors, Antigen, T-CellCD4-Positive T-LymphocytesCD8 AntigensCD8-Positive T-LymphocytesMiceTranscriptome

Keywords

T-cell receptorCytotoxic T cellCD8Cell biologyBiologyT cellTranscriptomeFunction (biology)TransgeneAntigenMolecular biologyCancer researchGene expressionImmunologyImmune systemGeneIn vitroBiochemistryCD4-Positive T-LymphocytesCD8 AntigensTCR, single-cell, T cell engineering, immunotherapy, leukemiaReceptors, Antigen, T-CellCD8-Positive T-LymphocytesMiceNeoplasmsAnimalsHumansResearch Articles

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being