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Caspase-8–dependent gasdermin D cleavage promotes antimicrobial defense but confers susceptibility to TNF-induced lethality

Science Advances(2020)10.1126/sciadv.abc3465Source: DataRank Database

Caspase-8–dependent gasdermin D cleavage promotes antimicrobial defense but confers susceptibility to TNF-induced lethality is a research paper published in Science Advances (2020). On theSindex it has a DataRank of 0. It has been cited 248 times.

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Open Access248 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (12 grants)Impact (FWCI 11.23)OA: goldTopics (28)Linked Datasets (22)DataCite Reuse (22)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

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Context only (not used in score)

Findable (2/2)

Has DOI
Indexed in repositories

Accessible (1/2)

Open Access

Interoperable (2/2)

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Reusable (0/3)

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Authors (14)

James P. Grayczyk ORCID,Elisabet Bjånes ORCID,Didier Le Roy ORCID,Wulf Tonnus ORCID,Charles-Antoine Assenmacher ORCID

Live enrichment

PubMed:33208362 PMC:PMC7673803 OpenAlex:https://openalex.org/W3101261873

National Institutes of Health

Grant: 1R21135421, 1R01128530

H2020 European Research Council

Grant: ERC2017?CoG?770988?InflamCellDeath

H2020 Marie Skłodowska-Curie Actions

Grant: MSCA?IF?2018?838252

Deutsche Forschungsgemeinschaft

Grant: SFB-TRR 205, SFB-TRR 127, IRTG 2251

Swiss National Science Foundation

Grant: SNSF 310030_173123

Swiss National Science Foundation

Grant: 175576

Swiss National Science Foundation

Grant: 310030

European Research Council

Grant: 770988

Swiss National Science Foundation

Grant: 173123

NIAID NIH HHS

Grant: R01 AI128530

NIAID NIH HHS

Grant: R01 AI139102

Burroughs Wellcome Fund

FWCI

11.23

Citation Percentile

1.0%

Citation Trend

2021

2022

2023

2024

2025

2026

goldLicense: cc-by-nc

journalhttps://advances.sciencemag.org/content/advances/6/47/eabc3465.full.pdf

publisherhttps://advances.sciencemag.org/content/advances/6/47/eabc3465.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1126/sciadv.abc3465

publisherhttps://www.science.org/doi/pdf/10.1126/sciadv.abc3465

journalhttps://doi.org/10.1126/sciadv.abc3465

Fields of Study

Inflammasome and immune disordersImmune Response and Inflammationinterferon and immune responsesAnti-Infective AgentsCaspase 8Intracellular Signaling Peptides and ProteinsPhosphate-Binding ProteinsTumor Necrosis Factor-alpha

MeSH Terms

Anti-Infective AgentsTumor Necrosis Factor-alphaPhosphate-Binding ProteinsIntracellular Signaling Peptides and ProteinsCaspase 8

Keywords

LethalityIn vivoTumor necrosis factor alphaCell biologyCleavage (geology)AntimicrobialChemistryMicrobiologyCaspaseApoptosisBiologyProgrammed cell deathImmunologyBiochemistryGenetics

Sustainable Development Goals

SDG 0: Good health and well-being

Additional file 3 of Umbilical cord mesenchymal stem cell-derived apoptotic extracellular vesicles ameliorate cutaneous wound healing in type 2 diabetic mice via macrophage pyroptosis inhibition

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Additional file 3 of Umbilical cord mesenchymal stem cell-derived apoptotic extracellular vesicles ameliorate cutaneous wound healing in type 2 diabetic mice via macrophage pyroptosis inhibition

10.6084/m9.figshare.24165026figshare

Additional file 4 of Umbilical cord mesenchymal stem cell-derived apoptotic extracellular vesicles ameliorate cutaneous wound healing in type 2 diabetic mice via macrophage pyroptosis inhibition

10.6084/m9.figshare.24165029.v1figshare

Additional file 4 of Umbilical cord mesenchymal stem cell-derived apoptotic extracellular vesicles ameliorate cutaneous wound healing in type 2 diabetic mice via macrophage pyroptosis inhibition

10.6084/m9.figshare.24165029figshare

Additional file 5 of Umbilical cord mesenchymal stem cell-derived apoptotic extracellular vesicles ameliorate cutaneous wound healing in type 2 diabetic mice via macrophage pyroptosis inhibition

10.6084/m9.figshare.24165032.v1figshare

Additional file 5 of Umbilical cord mesenchymal stem cell-derived apoptotic extracellular vesicles ameliorate cutaneous wound healing in type 2 diabetic mice via macrophage pyroptosis inhibition

10.6084/m9.figshare.24165032figshare

Additional file 1 of Identification of ANXA3 as a biomarker associated with pyroptosis in ischemic stroke

10.6084/m9.figshare.24844625.v1figshare

Additional file 1 of Identification of ANXA3 as a biomarker associated with pyroptosis in ischemic stroke

10.6084/m9.figshare.24844625figshare

Additional file 2 of Identification of ANXA3 as a biomarker associated with pyroptosis in ischemic stroke

10.6084/m9.figshare.24844751.v1figshare

Additional file 2 of Identification of ANXA3 as a biomarker associated with pyroptosis in ischemic stroke

10.6084/m9.figshare.24844751figshare

Additional file 3 of Identification of ANXA3 as a biomarker associated with pyroptosis in ischemic stroke

10.6084/m9.figshare.26654986.v1figshare

Additional file 3 of Identification of ANXA3 as a biomarker associated with pyroptosis in ischemic stroke

10.6084/m9.figshare.26654986figshare

Additional file 5 of Identification of ANXA3 as a biomarker associated with pyroptosis in ischemic stroke

10.6084/m9.figshare.26654992.v1figshare

Additional file 6 of Identification of ANXA3 as a biomarker associated with pyroptosis in ischemic stroke

10.6084/m9.figshare.26654995.v1figshare

Additional file 6 of Identification of ANXA3 as a biomarker associated with pyroptosis in ischemic stroke

10.6084/m9.figshare.26654995figshare

Additional file 4 of Identification of ANXA3 as a biomarker associated with pyroptosis in ischemic stroke

10.6084/m9.figshare.26654989figshare

Additional file 4 of Identification of ANXA3 as a biomarker associated with pyroptosis in ischemic stroke

10.6084/m9.figshare.26654989.v1figshare

Additional file 5 of Identification of ANXA3 as a biomarker associated with pyroptosis in ischemic stroke

10.6084/m9.figshare.26654992figshare

Additional file 2 of Umbilical cord mesenchymal stem cell-derived apoptotic extracellular vesicles ameliorate cutaneous wound healing in type 2 diabetic mice via macrophage pyroptosis inhibition

10.6084/m9.figshare.24165023.v1figshare

Additional file 1 of Umbilical cord mesenchymal stem cell-derived apoptotic extracellular vesicles ameliorate cutaneous wound healing in type 2 diabetic mice via macrophage pyroptosis inhibition

10.6084/m9.figshare.24165020.v1figshare