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FUS-ALS mutants alter FMRP phase separation equilibrium and impair protein translation

Science Advances(2021)10.1126/sciadv.abf8660Source: DataRank Database

FUS-ALS mutants alter FMRP phase separation equilibrium and impair protein translation is a research paper published in Science Advances (2021). On theSindex it has a DataRank of 0.631. It has been cited 66 times.

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0.631DataRank · unranked

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66 citations

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Enrichment:Funding (22 grants)OA: goldTopics (22)IDs (PubMed, PMC)Annotations (1)

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Accessible (0/2)

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 100%Citation Network 0%

Base Score Contribution

0.631

From this paper's citation signal

Citation Network Contribution

Citation network not refreshed for this result

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Authors (20)

Agnieszka M. Ule ORCID,Maria Giovanna Garone ORCID,Brian Tsang ORCID,Francesca Mattedi ORCID,P. Andrew Chong ORCID

Live enrichment

PubMed:34290090 PMC:PMC8294762

Medical Research Council

Grant: MR/M008606/1

Investigating deficits of axonal RNA metabolism and axonal signalling in amyotrophic lateral sclerosis

Medical Research Council

Grant: MR/S006508/1

The impact of TDP-43 on translation and the response to axonal damage in amyotrophic lateral sclerosis

Motor Neurone Disease Association

Grant: Fratta/Apr19/868-791

Rosetrees

Grant: M438-F1

Motor Neurone Disease Association

Grant: FISHER/APR14/874-792

Rosetrees

Grant: M599

Medical Research Council

Grant: MR/K018523/1

Medical Research Council

Grant: UKDRI-1005

Medical Research Council

Grant: MC_EX_MR/N501931/1

Medical Research Council

Grant: MR/R005184/1

Motor Neurone Disease Association

Grant: PLAGNOL/OCT15/885-792

Wellcome Trust

Grant: 107116/Z/15/Z

Motor Neurone Disease Association

Grant: Fratta/Apr19/893-792

Motor Neurone Disease Association

Grant: FRATTA/JAN15/946-795

Motor Neurone Disease Association

Grant: Fratta/Mar19/951-795

Medical Research Council

Grant: G0801110

Wellcome Trust

Grant: 107116

The mechanism controlling sorting and axonal retrograde transport in neurons.

Canadian Institutes of Health Research

Grant: unidentified

unidentified

Rosetrees Trust

Wellcome Trust

Motor Neurone Disease Association

UCLH Biomedical Research Centre

goldLicense: CC BY

publisherhttps://syndication.highwire.org/content/doi/10.1126/sciadv.abf8660

publisherhttps://www.science.org/doi/pdf/10.1126/sciadv.abf8660

Unpaywallhttps://doi.org/10.1126/sciadv.abf8660

Europe_PMChttps://europepmc.org/articles/PMC8294762

Europe_PMChttps://europepmc.org/articles/PMC8294762?pdf=render

Fields of Study

0301 basic medicine0303 health sciences03 medical and health sciences

MeSH Terms

AnimalsMiceAmyotrophic Lateral SclerosisNeurodegenerative DiseasesRNA-Binding Protein FUSProtein BiosynthesisMutationFragile X Messenger Ribonucleoprotein 1

Keywords

Fragile X Messenger Ribonucleoprotein 1Amyotrophic Lateral SclerosisNeurodegenerative DiseasesRNA-binding protein; Neurodegenerative diseases; Amyotrophic lateral sclerosis; Phase separation;MiceProtein BiosynthesisMutationAnimalsRNA-Binding Protein FUSBrain; Cell proliferation; Neurons; Phase separation; ProteinsResearch Articles

FUS-ALS mutants alter FMRP phase separation equilibrium and impair protein translation

FAIR Checklist

DataRank Breakdown

Authors (20)

Funding (22 grants)

Open Access

Topics

Annotations (Europe PMC)