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Microglia become hypofunctional and release metalloproteases and tau seeds when phagocytosing live neurons with P301S tau aggregates

Science Advances(2021)10.1126/sciadv.abg4980Source: DataRank Database

Microglia become hypofunctional and release metalloproteases and tau seeds when phagocytosing live neurons with P301S tau aggregates is a research paper published in Science Advances (2021). On theSindex it has a DataRank of 0. It has been cited 139 times.

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Enrichment:Funding (8 grants)Impact (FWCI 9.82)OA: goldTopics (34)Linked Datasets (20)DataCite Reuse (20)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

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Accessible (1/2)

Open Access

Interoperable (2/2)

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Reusable (0/3)

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Authors (7)

Matthew Mason ORCID,Panagiotis Katsinelos ORCID,William A. McEwan ORCID,Bernardino Ghetti ORCID,Aviva M. Tolkovsky ORCID

Live enrichment

PubMed:34669475 PMC:PMC8528424 OpenAlex:https://openalex.org/W3207250626

National Centre for the Replacement, Refinement and Reduction of Animals in Research

Grant: NC/L000741/1

NIA NIH HHS

Grant: P30 AG072976

NIA NIH HHS

Grant: P30 AG010133

Medical Research Council

Grant: UKDRI-2010

Wellcome Trust

Grant: 206248/Z/17/Z

National Institutes of Health

Grant: 5P30AG010133-08

CORE-- EDUCATION AND INFORMATION TRANSFER

European Commission

Grant: 116060

Inhibiting Misfolded protein PRopagation in Neurodegenerative Diseases - Sofia ref.: 116060

Wellcome Trust

Grant: 206248

Self-propagating protein conformations as targets of intracellular immunity

FWCI

9.82

Citation Percentile

1.0%

Influential Citations

Citation Trend

2021

2022

2023

2024

2025

2026

goldLicense: cc-by

journalhttps://doi.org/10.1126/sciadv.abg4980

GOLDhttps://doi.org/10.1126/sciadv.abg4980

publisherhttps://doi.org/10.1126/sciadv.abg4980

publisherhttps://www.science.org/doi/pdf/10.1126/sciadv.abg4980

repositoryhttps://pubmed.ncbi.nlm.nih.gov/34669475

Fields of Study

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatmentsS100 Proteins and AnnexinsMedicineBiology0301 basic medicine03 medical and health sciences

Keywords

MicrogliaPhagocytosisChemistryMetalloproteinaseNeuroscienceCell biologyMedicineBiologyImmunologyBiochemistryMatrix metalloproteinaseInflammationAgingFOS: Clinical medicineTau aggregatesNeurodegenerative diseasesNeurosciencesAlzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD)Neurodegenerative3101 Biochemistry and Cell BiologyAlzheimer's DiseaseBrain DisordersNeurologicalAcquired Cognitive Impairment2.1 Biological and endogenous factorsDementia31 Biological Sciences

Sustainable Development Goals

SDG 0: Zero hunger

Additional file 6 of PI3K-AKT activation resculpts integrin signaling to drive filamentous tau-induced proinflammatory astrogliosis

10.6084/m9.figshare.24208986.v1figshare

Additional file 6 of PI3K-AKT activation resculpts integrin signaling to drive filamentous tau-induced proinflammatory astrogliosis

10.6084/m9.figshare.24208986figshare

Additional file 1 of A 3D human co-culture to model neuron-astrocyte interactions in tauopathies

10.6084/m9.figshare.26570704.v1figshare

Additional file 1 of A 3D human co-culture to model neuron-astrocyte interactions in tauopathies

10.6084/m9.figshare.26570704figshare

Additional file 2 of A 3D human co-culture to model neuron-astrocyte interactions in tauopathies

10.6084/m9.figshare.26570707.v1figshare

Additional file 2 of A 3D human co-culture to model neuron-astrocyte interactions in tauopathies

10.6084/m9.figshare.26570707figshare

Additional file 8 of PI3K-AKT activation resculpts integrin signaling to drive filamentous tau-induced proinflammatory astrogliosis

10.6084/m9.figshare.24208992.v1figshare

Additional file 8 of PI3K-AKT activation resculpts integrin signaling to drive filamentous tau-induced proinflammatory astrogliosis

10.6084/m9.figshare.24208992figshare

Additional file 4 of PI3K-AKT activation resculpts integrin signaling to drive filamentous tau-induced proinflammatory astrogliosis

10.6084/m9.figshare.24208980figshare

Additional file 5 of PI3K-AKT activation resculpts integrin signaling to drive filamentous tau-induced proinflammatory astrogliosis

10.6084/m9.figshare.24208983.v1figshare

Additional file 4 of PI3K-AKT activation resculpts integrin signaling to drive filamentous tau-induced proinflammatory astrogliosis

10.6084/m9.figshare.24208980.v1figshare

Additional file 5 of PI3K-AKT activation resculpts integrin signaling to drive filamentous tau-induced proinflammatory astrogliosis

10.6084/m9.figshare.24208983figshare

Additional file 7 of PI3K-AKT activation resculpts integrin signaling to drive filamentous tau-induced proinflammatory astrogliosis

10.6084/m9.figshare.24208989figshare

Additional file 7 of PI3K-AKT activation resculpts integrin signaling to drive filamentous tau-induced proinflammatory astrogliosis

10.6084/m9.figshare.24208989.v1figshare

Additional file 1 of PI3K-AKT activation resculpts integrin signaling to drive filamentous tau-induced proinflammatory astrogliosis

10.6084/m9.figshare.24208971figshare

Additional file 3 of PI3K-AKT activation resculpts integrin signaling to drive filamentous tau-induced proinflammatory astrogliosis

10.6084/m9.figshare.24208977figshare

Additional file 3 of PI3K-AKT activation resculpts integrin signaling to drive filamentous tau-induced proinflammatory astrogliosis

10.6084/m9.figshare.24208977.v1figshare

Additional file 2 of PI3K-AKT activation resculpts integrin signaling to drive filamentous tau-induced proinflammatory astrogliosis

10.6084/m9.figshare.24208974figshare

Additional file 2 of PI3K-AKT activation resculpts integrin signaling to drive filamentous tau-induced proinflammatory astrogliosis

10.6084/m9.figshare.24208974.v1figshare

Additional file 1 of PI3K-AKT activation resculpts integrin signaling to drive filamentous tau-induced proinflammatory astrogliosis

10.6084/m9.figshare.24208971.v1figshare

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Microglia become hypofunctional and release metalloproteases and tau seeds when phagocytosing live neurons with P301S tau aggregates

FAIR Checklist

Authors (7)

Funding (8 grants)

Impact

Open Access

Topics

Linked Datasets (20)

Annotations (Europe PMC)

Related Papers (8)