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PI3-kinase deletion promotes myelodysplasia by dysregulating autophagy in hematopoietic stem cells

Science Advances(2023)10.1126/sciadv.ade8222Source: DataRank Database

PI3-kinase deletion promotes myelodysplasia by dysregulating autophagy in hematopoietic stem cells is a research paper published in Science Advances (2023). On theSindex it has a DataRank of 0. It has been cited 18 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access18 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (23 grants)Impact (FWCI 3.44)OA: goldTopics (43)IDs (PubMed, PMC, OpenAlex)Annotations (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (16)

Imit Kaur ORCID,Yang Shi ORCID,Meng Tong ORCID,Taneisha Sinclair ORCID,Shayda Hemmati

Live enrichment

PubMed:36812307 PMC:PMC9946350 OpenAlex:https://openalex.org/W4321481089

NIGMS NIH HHS

Grant: K12 GM102779

NIDDK NIH HHS

Grant: R56 DK130895

NCI NIH HHS

Grant: K08 CA149208

NCI NIH HHS

Grant: P30 CA008748

NCI NIH HHS

Grant: R01 CA196973

NIDDK NIH HHS

Grant: R01 DK130895

NIH HHS

Grant: S10 OD023591

NIGMS NIH HHS

Grant: T32 GM007491

NCI NIH HHS

Grant: P30 CA013330

NIH HHS

Grant: S10 OD026833

NCI NIH HHS

Grant: F31 CA247172

NHLBI NIH HHS

Grant: F32 HL146119

National Institutes of Health

Grant: 5T32GM007491-46

Training Program in Cellular and Molecular Biology and Genetics

National Institutes of Health

Grant: 3P30CA013330-39S3

Core Support for Cancer Center

National Institutes of Health

Grant: 1S10OD023591-01

Advanced Confocal Microscope in a multi-user facility

National Institutes of Health

Grant: 1ZIADK013039-04

Molecular modeling of soluble proteins

National Institutes of Health

Grant: 6K12GM102779-05

Bronx Einstein Training in Teaching and Research (BETTR)

National Institutes of Health

Grant: 1K08CA149208-01

The p110 alpha and delta isoforms of PI3 kinase in hematopoiesis and leukemia

National Institutes of Health

Grant: 1F32HL146119-01A1

Role of the Class IA PI3K in Hematopoietic Stem Cell Self-Renewal

National Institutes of Health

Grant: 1R56DK130895-01

PI3 Kinase Inactivation in Myelodysplastic Syndrome

National Institutes of Health

Grant: 5F31CA247172-02

RON kinase as a novel therapeutic target in myeloproliferative neoplasms

National Institutes of Health

Grant: 1S10OD026833-01

Cytek Aurora Multiparameter Flow Cytometer

National Institutes of Health

Grant: 5R01CA196973-05

PI3K Isoform Dependence in Adult Hematopoiesis and Myeloid Leukemia

FWCI

3.44

Citation Percentile

0.9%

Citation Trend

2023

2024

2025

2026

goldLicense: cc-by

journalhttps://www.science.org/doi/pdf/10.1126/sciadv.ade8222?download=true

publisherhttps://www.science.org/doi/pdf/10.1126/sciadv.ade8222?download=true

publisherhttps://www.science.org/doi/pdf/10.1126/sciadv.ade8222

journalhttps://doi.org/10.1126/sciadv.ade8222

repositoryhttps://pubmed.ncbi.nlm.nih.gov/36812307

Fields of Study

Autophagy in Disease and TherapyAcute Myeloid Leukemia ResearchHistone Deacetylase Inhibitors Research0301 basic medicine03 medical and health sciencesMiceAnimalsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktHematopoietic Stem CellsMyelodysplastic SyndromesCell DifferentiationMice, Knockout

MeSH Terms

AnimalsCell DifferentiationHematopoietic Stem CellsMyelodysplastic SyndromesMice, KnockoutPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktMice

Keywords

PI3K/AKT/mTOR pathwayAutophagyHaematopoiesisCancer researchBiologyStem cellProtein kinase BCell biologyMyeloidHematopoietic stem cellSignal transductionGeneticsApoptosisMice, KnockoutMicePhosphatidylinositol 3-KinasesMyelodysplastic SyndromesAnimalsCell DifferentiationBiomedicine and Life SciencesHematopoietic Stem CellsProto-Oncogene Proteins c-akt