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Microphysiological model of PIK3CA-driven vascular malformations reveals a role of dysregulated Rac1 and mTORC1/2 in lesion formation

Science Advances(2023)10.1126/sciadv.ade8939Source: DataRank Database

Microphysiological model of PIK3CA-driven vascular malformations reveals a role of dysregulated Rac1 and mTORC1/2 in lesion formation is a research paper published in Science Advances (2023). On theSindex it has a DataRank of 0. It has been cited 26 times.

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Open Access26 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (5 grants)OA: goldTopics (18)IDs (PubMed, PMC)

FAIR Checklist

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Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (15)

Crescentia Cho ORCID,Hao Wang ORCID,Anne Hope Cooper,Elizabeth L. Doherty ORCID,David J. Rocco ORCID

Live enrichment

PubMed:36791204 PMC:PMC9931220

NIGMS NIH HHS

Grant: T32 GM133393

NHLBI NIH HHS

Grant: F31 HL162462

NIGMS NIH HHS

Grant: R35 GM142944

NIDDK NIH HHS

Grant: T32 DK007750

NHLBI NIH HHS

Grant: T32 HL069768

goldLicense: cc-by-nc

publisherhttps://www.science.org/doi/pdf/10.1126/sciadv.ade8939?download=true

publisherhttps://www.science.org/doi/pdf/10.1126/sciadv.ade8939

repositoryhttps://escholarship.org/content/qt3863j9kv/qt3863j9kv.pdf

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC9931220/pdf/sciadv.ade8939.pdf

Unpaywallhttps://escholarship.org/uc/item/3863j9kv

Fields of Study

HumansTOR Serine-Threonine KinasesMechanistic Target of Rapamycin Complex 1SirolimusHuman Umbilical Vein Endothelial CellsMitogen-Activated Protein Kinase KinasesClass I Phosphatidylinositol 3-KinasesVascular Malformationsrac1 GTP-Binding Protein

MeSH Terms

HumansSirolimusrac1 GTP-Binding ProteinMitogen-Activated Protein Kinase KinasesVascular MalformationsClass I Phosphatidylinositol 3-KinasesTOR Serine-Threonine KinasesHuman Umbilical Vein Endothelial CellsMechanistic Target of Rapamycin Complex 1