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RAS-dependent RAF-MAPK hyperactivation by pathogenic RIT1 is a therapeutic target in Noonan syndrome–associated cardiac hypertrophy

Science Advances(2023)10.1126/sciadv.adf4766Source: DataRank Database

RAS-dependent RAF-MAPK hyperactivation by pathogenic RIT1 is a therapeutic target in Noonan syndrome–associated cardiac hypertrophy is a research paper published in Science Advances (2023). On theSindex it has a DataRank of 0. It has been cited 25 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access25 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (5 grants)Impact (FWCI 3.36)OA: goldTopics (26)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (15)

Morgan E. Wagner ORCID,Richard Van ORCID,Monalisa Swain,Stephanie Mo ORCID,John Columbus

Live enrichment

PubMed:37450595 PMC:PMC10348673 OpenAlex:https://openalex.org/W4384296957

NCI NIH HHS

Grant: F31 CA265066

NCI NIH HHS

Grant: 75N91019D00024

NCI NIH HHS

Grant: R00 CA245122

NCI NIH HHS

Grant: R35 CA197709

NCI NIH HHS

Grant: U54 CA196519

FWCI

3.36

Citation Percentile

0.9%

Citation Trend

2023

2024

2025

2026

goldLicense: cc-by

journalhttps://www.science.org/doi/pdf/10.1126/sciadv.adf4766?download=true

publisherhttps://www.science.org/doi/pdf/10.1126/sciadv.adf4766?download=true

publisherhttps://www.science.org/doi/pdf/10.1126/sciadv.adf4766

journalhttps://doi.org/10.1126/sciadv.adf4766

repositoryhttps://pubmed.ncbi.nlm.nih.gov/37450595

Fields of Study

Protein Tyrosine PhosphatasesGalectins and Cancer BiologyPeptidase Inhibition and AnalysisAnimalsMiceNoonan SyndromeMitogen-Activated Protein KinasesCardiomegalySignal TransductionLung Neoplasms

MeSH Terms

AnimalsCardiomegalyLung NeoplasmsNoonan SyndromeSignal TransductionMitogen-Activated Protein KinasesMice

Keywords

MAPK/ERK pathwayKinaseNoonan syndromeCancer researchBiologyCell biologySignal transductionProtein kinase AGenetics

Sustainable Development Goals

SDG 0: Good health and well-being