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An SPNS1-dependent lysosomal lipid transport pathway that enables cell survival under choline limitation

Science Advances(2023)10.1126/sciadv.adf8966Source: DataRank Database

An SPNS1-dependent lysosomal lipid transport pathway that enables cell survival under choline limitation is a research paper published in Science Advances (2023). On theSindex it has a DataRank of 0. It has been cited 46 times.

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Open Access46 citations

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cellosaurus uniprot

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (6 grants)Impact (FWCI 6.58)OA: goldTopics (29)Linked Datasets (2)DataCite Reuse (2)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (2/2)

Has DOI
Indexed in repositories

Accessible (1/2)

Open Access

Interoperable (2/2)

DataCite relations
Linked datasets

Reusable (0/3)

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Authors (10)

Wentao Dong ORCID,Ali Ghoochani ORCID,Kwamina Nyame ORCID,Roni Levin‐Konigsberg ORCID,Aswini R. Krishnan ORCID

Live enrichment

PubMed:37075117 PMC:PMC10115416 OpenAlex:https://openalex.org/W4366382667

NCI NIH HHS

Grant: DP2 CA271386

NIGMS NIH HHS

Grant: T32 GM007365

NIGMS NIH HHS

Grant: T32 GM145402

National Institutes of Health

Grant: 4DP2CA271386-02

Innovations and mechanisms in tumor subcellular metabolism

National Institutes of Health

Grant: 5T32GM007365-23

MEDICAL SCIENTIST TRAINING PROGRAM

National Institutes of Health

Grant: 5T32GM139791-03

Stanford ChEM-H Chemistry/Biology Interface Predoctoral Training Program

FWCI

6.58

Citation Percentile

1.0%

Influential Citations

Citation Trend

2023

2024

2025

2026

goldLicense: cc-by

journalhttps://doi.org/10.1126/sciadv.adf8966

GOLDhttps://doi.org/10.1126/sciadv.adf8966

publisherhttps://doi.org/10.1126/sciadv.adf8966

publisherhttps://www.science.org/doi/pdf/10.1126/sciadv.adf8966

repositoryhttps://pubmed.ncbi.nlm.nih.gov/37075117

Fields of Study

Lysosomal Storage Disorders ResearchCellular transport and secretionCalcium signaling and nucleotide metabolismMedicineBiology0301 basic medicine03 medical and health sciencesCholineCell SurvivalPhospholipidsPhosphatidylcholinesLysosomes

MeSH Terms

Cell SurvivalCholineLysosomesPhosphatidylcholinesPhospholipids

Keywords

CholineCell biologyCell survivalChemistryLipid dropletBiologyBiochemistryApoptosisPhosphatidylcholinesBiomedicine and Life SciencesLysosomesPhospholipids

Sustainable Development Goals

SDG 0: Life in Land

Lipidomic profiling of SPNS1-KO lysosomes

10.5061/dryad.hqbzkh1mkDryad

CRISPR/Cas9 screen for essential endolysosomal genes under free choline limitation

10.5061/dryad.wm37pvms7Dryad

An SPNS1-dependent lysosomal lipid transport pathway that enables cell survival under choline limitation

FAIR Checklist

Authors (10)

Funding (6 grants)

Impact

Open Access

Topics

Linked Datasets (2)

Annotations (Europe PMC)