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Sequential CRISPR screening reveals partial NatB inhibition as a strategy to mitigate alpha-synuclein levels in human neurons

Science Advances(2024)10.1126/sciadv.adj4767Source: DataRank Database

Sequential CRISPR screening reveals partial NatB inhibition as a strategy to mitigate alpha-synuclein levels in human neurons is a research paper published in Science Advances (2024). On theSindex it has a DataRank of 0. It has been cited 17 times.

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Open Access17 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (21 grants)Impact (FWCI 3.17)OA: goldTopics (45)IDs (PubMed, PMC, OpenAlex)Annotations (3)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (14)

Nima Naseri ORCID,Sarshan R. Pather ORCID,Erinc Hallacli ORCID,Alain Ndayisaba ORCID,Chris Buenaventura

Live enrichment

PubMed:38335281 PMC:PMC10857481 OpenAlex:https://openalex.org/W4391677843

NIH HHS

Grant: S10 OD030460

NIGMS NIH HHS

Grant: T32 GM132039

NINDS NIH HHS

Grant: R01 NS109209

NINDS NIH HHS

Grant: R01 NS128142

NIA NIH HHS

Grant: F32 AG079537

NIGMS NIH HHS

Grant: DP2 GM137416

NINDS NIH HHS

Grant: R01 NS088322

NINDS NIH HHS

Grant: R01 NS120625

NINDS NIH HHS

Grant: R03 NS111447

NIA NIH HHS

Grant: U19 AG062418

National Institutes of Health

Grant: 1R13AG013039-01

1995 SUMMER INSTITUTE IN GERIATRIC MEDICINE

National Institutes of Health

Grant: 1R03NS111447-01

Dissecting the mechanisms that underlie mislocalization and aggregation of RNA binding proteins in neurodegenerative diseases

National Institutes of Health

Grant: 5R01NS109209-05

Elucidating the Biological Differences Between Distinct Fibrillar and Non-Fibrillar Alpha-Synuclein Inclusions in Human Stem-Cell Models

National Institutes of Health

Grant: 1R01NS120625-01A1

Structural basis and physiological consequences of alpha-Synuclein binding to neurexin 1beta

National Institutes of Health

Grant: 1S10OD030460-01

Bruker RapifleX MALDI TOF/TOF Mass Spectrometer

National Institutes of Health

Grant: 5U19AG062418-02

Center On Alpha-synuclein Strains In Alzheimer Disease & Related Dementias

National Institutes of Health

Grant: 1T32GM132039-01

Structural biology and molecular biophysics training program

National Institutes of Health

Grant: 5R01NS088322-05

Propagation of Lewy pathology in Parkinsons disease

National Institutes of Health

Grant: 1R01NS128142-01A1

Investigating physiologic and pathophysiologic connections between the Parkinson's disease protein alpha-synuclein and RNA binding proteins

National Institutes of Health

Grant: 1F32AG079537-01

Isoform-dependent effects of tau phosphorylation in Alzheimer's disease

National Institutes of Health

Grant: 1DP2GM137416-01

Direct and rapid control of proteins at scale

FWCI

3.17

Citation Percentile

0.9%

Citation Trend

2024

2025

2026

goldLicense: cc-by-nc

journalhttps://www.science.org/doi/pdf/10.1126/sciadv.adj4767?download=true

publisherhttps://www.science.org/doi/pdf/10.1126/sciadv.adj4767?download=true

publisherhttps://www.science.org/doi/pdf/10.1126/sciadv.adj4767

journalhttps://doi.org/10.1126/sciadv.adj4767

repositoryhttps://pubmed.ncbi.nlm.nih.gov/38335281

Fields of Study

CRISPR and Genetic EngineeringParkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling0301 basic medicine0303 health sciences03 medical and health sciencesHumansalpha-SynucleinCell LineClustered Regularly Interspaced Short Palindromic RepeatsNeuronsParkinson DiseaseN-Terminal Acetyltransferase BMethionyl Aminopeptidases

MeSH Terms

Cell LineHumansNeuronsParkinson Diseasealpha-SynucleinMethionyl AminopeptidasesN-Terminal Acetyltransferase BClustered Regularly Interspaced Short Palindromic Repeats

Keywords

SynucleinopathiesEndogenyBiologyProteasomeAlpha-synucleinRegulatorAcetylationCell biologyInduced pluripotent stem cellGeneParkinson's diseaseBiochemistryDiseaseEmbryonic stem cellMedicineNeuronsHumansMethionyl AminopeptidasesClustered Regularly Interspaced Short Palindromic RepeatsParkinson DiseaseN-Terminal Acetyltransferase BNeuroscienceCell Line

Sustainable Development Goals

SDG 0: Good health and well-being