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A potent and selective ENL degrader suppresses oncogenic gene expression and leukemia progression

Science Advances(2024)10.1126/sciadv.ado1432Source: DataRank Database

A potent and selective ENL degrader suppresses oncogenic gene expression and leukemia progression is a research paper published in Science Advances (2024). On theSindex it has a DataRank of 0. It has been cited 14 times.

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Scored on demand from live citation data

Open Access14 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (17 grants)Impact (FWCI 2.61)OA: goldTopics (51)IDs (PubMed, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (15)

Lihuai Qin ORCID,Hongwen Xuan ORCID,Kaixiu Luo ORCID,Mengying Huang ORCID,Ling Xie ORCID

Live enrichment

PubMed:39196923 OpenAlex:https://openalex.org/W4401944571

National Institutes of Health

Grant: 5R01GM133107-02

Molecular mechanisms of CIB1 signaling

National Institutes of Health

Grant: 1R01CA268440-01

High Throughput Screen for Inhibitors of the YEATS2 Histone Acylation Reader

National Institutes of Health

Grant: 1R21AG071229-01

Deciphering the non-canonical function of the histone methyltransferase G9a in the etiology of AD

National Institutes of Health

Grant: 1R13AG013039-01

1995 SUMMER INSTITUTE IN GERIATRIC MEDICINE

National Institutes of Health

Grant: 1R41DK133051-01A1

Novel therapeutic intervention of early-stage T1D

National Institutes of Health

Grant: 1S10OD025132-01A1

An AVANCE NEO 600 MHz NMR Spectrometer System for Structural and Chemical Biology

National Institutes of Health

Grant: 1R01CA255506-01

Discovery of small molecules targeting the histone acetylation reader ENL

National Institutes of Health

Grant: 5R01CA260666-05

Development of Novel PROTACs Targeting the ENL YEATS Domain for Treating MLL-rearranged Leukemias

National Institutes of Health

Grant: 1S10OD028504-01

An AVANCE NEO 400 MHz NMR Spectrometer for Chemical Biology and Drug Discovery

NIH HHS

Grant: S10 OD028504

NCI NIH HHS

Grant: R01 CA255506

NIA NIH HHS

Grant: R21 AG071229

NIDDK NIH HHS

Grant: R41 DK133051

NIH HHS

Grant: S10 OD025132

NIGMS NIH HHS

Grant: R01 GM133107

NCI NIH HHS

Grant: R01 CA268440

NCI NIH HHS

Grant: R01 CA260666

FWCI

2.61

Citation Percentile

0.9%

Citation Trend

2025

2026

goldLicense: cc-by-nc

journalhttps://www.science.org/doi/pdf/10.1126/sciadv.ado1432?download=true

publisherhttps://www.science.org/doi/pdf/10.1126/sciadv.ado1432?download=true

publisherhttps://www.science.org/doi/pdf/10.1126/sciadv.ado1432

journalhttps://doi.org/10.1126/sciadv.ado1432

repositoryhttps://pubmed.ncbi.nlm.nih.gov/39196923

Fields of Study

Protein Degradation and InhibitorsGenomics and Chromatin DynamicsHistone Deacetylase Inhibitors Research0301 basic medicine0303 health sciences03 medical and health sciencesHumansAnimalsMiceCell Line, TumorDisease ProgressionLeukemiaTranscriptional Elongation FactorsXenograft Model Antitumor AssaysGene Expression Regulation, LeukemicProteolysisVon Hippel-Lindau Tumor Suppressor ProteinCell Proliferation

MeSH Terms

AnimalsHumansLeukemiaGene Expression Regulation, LeukemicDisease ProgressionXenograft Model Antitumor AssaysTranscriptional Elongation FactorsCell Line, TumorCell ProliferationMiceVon Hippel-Lindau Tumor Suppressor ProteinProteolysis

Keywords

LeukemiaCancer researchBiologyCarcinogenesisHistoneChromatinMdm2GeneGeneticsGene Expression Regulation, LeukemicXenograft Model Antitumor AssaysMiceVon Hippel-Lindau Tumor Suppressor ProteinCell Line, TumorProteolysisDisease ProgressionHumansAnimalsBiomedicine and Life SciencesTranscriptional Elongation FactorsCell Proliferation

Sustainable Development Goals

SDG 0: Good health and well-being