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Proteomimetic polymer blocks mitochondrial damage, rescues Huntington’s neurons, and slows onset of neuropathology in vivo

Science Advances(2024)10.1126/sciadv.ado8307Source: DataRank Database

Proteomimetic polymer blocks mitochondrial damage, rescues Huntington’s neurons, and slows onset of neuropathology in vivo is a research paper published in Science Advances (2024). On theSindex it has a DataRank of 0. It has been cited 4 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access4 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (17 grants)Impact (FWCI 0.87)OA: goldTopics (54)IDs (PubMed, PMC, OpenAlex)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (12)

Mara Fattah ORCID,Yutong Shang ORCID,Matthew P. Thompson ORCID,Kendal P. Carrow ORCID,Di Hu ORCID

Live enrichment

PubMed:39485846 PMC:PMC11529722 OpenAlex:https://openalex.org/W4403969419

NIA NIH HHS

Grant: R01 AG076051

NIA NIH HHS

Grant: F30 AG076317

NIA NIH HHS

Grant: F31 AG076334

NIA NIH HHS

Grant: R01 AG065240

NINDS NIH HHS

Grant: R01 NS115903

NCI NIH HHS

Grant: P30 CA060553

NIA NIH HHS

Grant: RF1 AG074346

National Institutes of Health

Grant: 1R01AG076051-01

Mechanism of white matter pathology in Alzheimer's disease

National Institutes of Health

Grant: 5R01NS115903-03

Proteostasis dysregulation and alpha-synuclein

National Institutes of Health

Grant: 1RF1AG074346-01A1

Regulation of CHCHD6 in Alzheimer's disease

National Institutes of Health

Grant: 1R13AG013039-01

1995 SUMMER INSTITUTE IN GERIATRIC MEDICINE

National Institutes of Health

Grant: 1R01AG065240-01

Role of brain lipid metabolism in Alzheimer's disease

National Institutes of Health

Grant: 5P30CA060553-12

The Robert H.Lurie Comprehensive Cancer Center

National Science Foundation

Grant: 2025633

NNCI: Soft Hybrid Nanotechnology Experimental (SHyNE) Resource

National Institutes of Health

Grant: 5F30AG076317-04

Development of Protein Like Polymer Therapeutics for Modulating the Nrf2/Keap1 Protein Protein Interaction in Neurodegenerative Diseases

National Science Foundation

Grant: 1048773

Upgrade of 400 MHz NMR Capabilities for Research, Education and Outreach

National Institutes of Health

Grant: 5F31AG076334-02

Development of Novel Synthetic Proteomimetics for Mediating Tauopathy in Alzheimer's Disease

FWCI

0.87

Citation Percentile

0.7%

Citation Trend

2025

2026

goldLicense: cc-by-nc

journalhttps://www.science.org/doi/pdf/10.1126/sciadv.ado8307?download=true

publisherhttps://www.science.org/doi/pdf/10.1126/sciadv.ado8307?download=true

publisherhttps://www.science.org/doi/pdf/10.1126/sciadv.ado8307

journalhttps://doi.org/10.1126/sciadv.ado8307

repositoryhttps://pubmed.ncbi.nlm.nih.gov/39485846

Fields of Study

Genetic Neurodegenerative DiseasesMitochondrial Function and PathologyLanthanide and Transition Metal Complexes0301 basic medicine0303 health sciences03 medical and health sciencesAnimalsHuntington DiseaseMitochondriaNeuronsMiceMice, TransgenicDisease Models, AnimalHuntingtin ProteinHumansPolymersValosin Containing ProteinPeptides

MeSH Terms

Huntingtin ProteinValosin Containing ProteinAnimalsDisease Models, AnimalHumansHuntington DiseaseMice, TransgenicMitochondriaNeuronsPeptidesPolymersMice

Keywords

NeuropathologyHuntington's diseaseIn vivoNeuroscienceMitochondrionBiologyCell biologyMedicinePathologyGeneticsDiseaseNeuronsHuntingtin ProteinPolymersMice, TransgenicMitochondriaMiceDisease Models, AnimalHuntington DiseaseValosin Containing ProteinAnimalsHumansBiomedicine and Life SciencesPeptides