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Epigenetic regulation of p63 blocks squamous-to-neuroendocrine transdifferentiation in esophageal development and malignancy

Science Advances(2024)10.1126/sciadv.adq0479Source: DataRank Database

Epigenetic regulation of p63 blocks squamous-to-neuroendocrine transdifferentiation in esophageal development and malignancy is a research paper published in Science Advances (2024). On theSindex it has a DataRank of 0. It has been cited 9 times.

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Open Access9 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (24 grants)Impact (FWCI 2.58)OA: goldTopics (49)IDs (PubMed, PMC, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (24)

Dimitris Karagiannis ORCID,Helu Liu ORCID,Mi Lin ORCID,Yinshan Fang ORCID,Ming Jiang ORCID

Live enrichment

PubMed:39383220 PMC:PMC11463268 OpenAlex:https://openalex.org/W4403277426

NIH HHS

Grant: S10 OD032447

NIAMS NIH HHS

Grant: R01 AR073170

NIDCR NIH HHS

Grant: R01 DE031873

NIH HHS

Grant: S10 OD020056

NCI NIH HHS

Grant: P01 CA268991

NCI NIH HHS

Grant: P01 CA098101

NCI NIH HHS

Grant: P30 CA013696

NCI NIH HHS

Grant: R01 CA272901

NIDDK NIH HHS

Grant: R01 DK120650

BLRD VA

Grant: IK6 BX006300

NIDDK NIH HHS

Grant: P30 DK132710

BLRD VA

Grant: I01 BX002115

NIDDK NIH HHS

Grant: R01 DK132251

National Institutes of Health

Grant: 1R01DK132251-01

Cell Fate Regulation in Esophageal Progenitor Cells

National Institutes of Health

Grant: 1P30DK132710-01

The Columbia University Digestive and Liver Disease Research Center

National Institutes of Health

Grant: 1ZIADK013039-04

Molecular modeling of soluble proteins

National Institutes of Health

Grant: 3P30CA013696-21S1

CANCER CENTER CORE SUPPORT GRANT

National Institutes of Health

Grant: 5P01CA098101-07

Molecular Biology/Gene Expression Core

National Institutes of Health

Grant: 1S10OD032447-01

Leica Stellaris 8 Confocal Microscope

National Institutes of Health

Grant: 1S10OD020056-01

BD Biosciences Influx

National Institutes of Health

Grant: 5R01DE031873-04

Epigenetic Regulation of Head and Neck Cancer Immune Evasion

National Institutes of Health

Grant: 1R01DK120650-01

Signaling Mechanisms Promoting Barrett’s Metaplasia

National Institutes of Health

Grant: 1P01CA268991-01

Disruption of Transcription Networks in Esophageal Adenocarcinoma Tumorigenesis

National Institutes of Health

Grant: 4R01CA272901-04

Gastroesophageal junction stem cells as the origin of Barretts esophagus and cancer

FWCI

2.58

Citation Percentile

0.9%

Citation Trend

2025

goldLicense: cc-by-nc

journalhttps://www.science.org/doi/pdf/10.1126/sciadv.adq0479?download=true

publisherhttps://www.science.org/doi/pdf/10.1126/sciadv.adq0479?download=true

publisherhttps://www.science.org/doi/pdf/10.1126/sciadv.adq0479

journalhttps://doi.org/10.1126/sciadv.adq0479

repositoryhttps://pubmed.ncbi.nlm.nih.gov/39383220

Fields of Study

Neuroendocrine Tumor Research AdvancesLung Cancer Research StudiesEpigenetics and DNA Methylation0301 basic medicine03 medical and health sciences

MeSH Terms

Enhancer of Zeste Homolog 2 ProteinAnimalsEsophageal NeoplasmsEsophagusHumansTranscription FactorsTrans-ActivatorsGene Expression Regulation, NeoplasticCarcinoma, NeuroendocrineTumor Suppressor ProteinsEpigenesis, GeneticCell Line, TumorMiceCell TransdifferentiationNeuroendocrine Cells

Keywords

TransdifferentiationEpigeneticsMalignancyMedicineEsophageal cancerCancer researchBiologyBioinformaticsInternal medicineCancerGeneticsStem cellGeneEsophageal NeoplasmsTumor Suppressor ProteinsEpigenesis, GeneticCarcinoma, NeuroendocrineGene Expression Regulation, NeoplasticMiceEsophagusNeuroendocrine CellsCell Line, TumorCell TransdifferentiationTrans-ActivatorsHumansAnimalsEnhancer of Zeste Homolog 2 ProteinBiomedicine and Life SciencesTranscription Factors

Sustainable Development Goals

SDG 0: Good health and well-being