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Structure and dynamics determine G protein coupling specificity at a class A GPCR

Science Advances(2025)10.1126/sciadv.adq3971Source: DataRank Database

Structure and dynamics determine G protein coupling specificity at a class A GPCR is a research paper published in Science Advances (2025). On theSindex it has a DataRank of 0. It has been cited 38 times.

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Open Access38 citations

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Enrichment:Funding (15 grants)OA: goldTopics (39)IDs (PubMed, PMC)Annotations (1)

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Authors (23)

Haoqing Wang ORCID,Patrick J. Brennan ORCID,Chris Habrian,Harald Hübner ORCID,Maximilian F. Schmidt ORCID

Live enrichment

PubMed:40106559 PMC:PMC12101717

NHLBI NIH HHS

Grant: F31 HL164002

BLRD VA

Grant: I01 BX005100

NHLBI NIH HHS

Grant: R01 HL162825

BLRD VA

Grant: IK6 BX005753

NIMH NIH HHS

Grant: R01 MH134119

NIH HHS

Grant: S10 OD025260

NINDS NIH HHS

Grant: R01 NS028471

NIGMS NIH HHS

Grant: R01 GM083118

NINDS NIH HHS

Grant: R01 NS119826

NIGMS NIH HHS

Grant: R01 GM135581

NIH HHS

Grant: S10 OD024980

National Science Foundation

Grant: 1942957

CAREER:Experimental Studies of Protein Thermodynamics Facilitated by NMR with Reverse Micelles

European Commission

Grant: 799376

Allosteric modulation of G-protein Coupled Receptors conformational landscape

National Institutes of Health

Grant: 5R01GM135581-02

Regulation of beta2-adrenergic receptor signaling by post-translational modifications

Deutsche Forschungsgemeinschaft

Grant: 222125149/GRK 1910

Medicinal Chemistry of Selective GPCR Ligands

goldLicense: cc-by

publisherhttps://www.science.org/history/e4336b7a-f281-40ea-a1e2-572e3f816409/sciadv.adq3971.v1.pdf

publisherhttps://www.science.org/doi/pdf/10.1126/sciadv.adq3971

repositoryhttps://hdl.handle.net/2434/1177096

repositoryhttps://escholarship.org/uc/item/6rs366z7

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/12101717

Fields of Study

0301 basic medicine03 medical and health sciences

MeSH Terms

HumansGTP-Binding ProteinsGTP-Binding Protein alpha Subunits, GsReceptors, G-Protein-CoupledReceptors, Adrenergic, beta-2LigandsSignal TransductionProtein ConformationProtein BindingModels, MolecularHEK293 Cells

Keywords

Models, MolecularProtein Conformation1.1 Normal biological development and functioningbeta-2LigandsReceptors, G-Protein-CoupledGsG-Protein-CoupledModelsGTP-Binding ProteinsReceptorsGTP-Binding Protein alpha Subunits, GsHumansMolecularBiological SciencesGTP-Binding Protein alpha SubunitsGood Health and Well BeingHEK293 CellsAdrenergicChemical SciencesBiochemistry and Cell BiologyGeneric health relevanceBiomedicine and Life SciencesReceptors, Adrenergic, beta-2Signal TransductionProtein Binding