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Mitochondrial calcium signaling regulates branched-chain amino acid catabolism in fibrolamellar carcinoma

Science Advances(2025)10.1126/sciadv.adu9512Source: DataRank Database

Mitochondrial calcium signaling regulates branched-chain amino acid catabolism in fibrolamellar carcinoma is a research paper published in Science Advances (2025). On theSindex it has a DataRank of 0. It has been cited 6 times.

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Open Access6 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (18 grants)Impact (FWCI 3.39)OA: goldTopics (51)IDs (PubMed, PMC, OpenAlex)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (18)

Melissa J. S. MacEwen ORCID,Jane Chea,Heidi L. Kenerson ORCID,Albert A. Kwong,Timothy M. Locke ORCID

Live enrichment

PubMed:40435263 PMC:PMC12118637 OpenAlex:https://openalex.org/W4410809547

NIEHS NIH HHS

Grant: P30 ES007033

NCI NIH HHS

Grant: P30 CA015704

NCI NIH HHS

Grant: R01 CA279997

NIGMS NIH HHS

Grant: R01 GM129090

NIA NIH HHS

Grant: F31 AG072716

NIGMS NIH HHS

Grant: R35 GM136234

NIGMS NIH HHS

Grant: R35 GM147118

NIH HHS

Grant: S10 OD021502

National Science Foundation

Grant: 2314338

Fundamental Studies on the Regulation and Interaction of Ceramides in Cellular Senescence and Cell Death

National Institutes of Health

Grant: 1F32GM013039-01

MOLECULAR ANALYSIS OF THE YEAST HEAT SHOCK TRANSCRIPTION

National Institutes of Health

Grant: 1F31AG072716-01A1

Investigating Calcium Homeostasis During a Key Mitochondrial Stress Pathway

National Institutes of Health

Grant: 1S10OD021502-01A1

A NanoLC-Orbitrap Tribrid Instrument for Comprehensive Proteomics Analyses

National Institutes of Health

Grant: 5R01CA279997-02

Targeting Oncogenic PKA signaling mechanisms

National Institutes of Health

Grant: 3P30CA015704-42S2

Cancer Center Support Grant

National Institutes of Health

Grant: 3P30ES007033-18S1

Center for Ecogenetics and Environmental Health

National Institutes of Health

Grant: 5R35GM147118-04

Understanding metabolic functions of mitochondria in proliferating cells

National Institutes of Health

Grant: 5R35GM136234-02

Role of sumoylation during stress signaling responses

National Institutes of Health

Grant: 5R01GM129090-04

Defining Pathway-Specific Kinase Signaling Modules with Proteomics

FWCI

3.39

Citation Percentile

0.9%

Citation Trend

2025

2026

goldLicense: cc-by-nc

journalhttps://www.science.org/doi/pdf/10.1126/sciadv.adu9512?download=true

publisherhttps://www.science.org/doi/pdf/10.1126/sciadv.adu9512?download=true

publisherhttps://www.science.org/doi/pdf/10.1126/sciadv.adu9512

journalhttps://doi.org/10.1126/sciadv.adu9512

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40435263

Fields of Study

Mitochondrial Function and PathologyCancer, Hypoxia, and MetabolismMetabolism and Genetic DisordersAmino Acids, Branched-ChainCarcinoma, HepatocellularHumansLiver NeoplasmsMitochondriaCalcium SignalingCell Line, TumorCalcium ChannelsKruppel-Like Transcription FactorsGene Expression Regulation, NeoplasticFibrolamellar hepatocellular carcinoma

MeSH Terms

Amino Acids, Branched-ChainCarcinoma, HepatocellularHumansLiver NeoplasmsMitochondriaCalcium ChannelsGene Expression Regulation, NeoplasticCalcium SignalingCell Line, TumorKruppel-Like Transcription Factors

Keywords

UniporterBiologyCatabolismUrea cycleMitochondrionCell biologyCalcium signalingBiochemistryMetabolic pathwayMetabolismSignal transductionAmino acidEnzymeCytosolArginineGene Expression Regulation, NeoplasticCarcinoma, Hepatocellular1000 GeneralCell Line, TumorLiver NeoplasmsKruppel-Like Transcription FactorsHumansBiomedicine and Life SciencesCalcium ChannelsArticleAmino Acids, Branched-ChainMitochondria