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Strategy to overcome a nirmatrelvir resistance mechanism in the SARS-CoV-2 nsp5 protease

Science Advances(2025)10.1126/sciadv.adv8875Source: DataRank Database

Strategy to overcome a nirmatrelvir resistance mechanism in the SARS-CoV-2 nsp5 protease is a research paper published in Science Advances (2025). On theSindex it has a DataRank of 0. It has been cited 10 times.

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Scored on demand from live citation data

Open Access10 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (18 grants)Impact (FWCI 8.99)OA: goldTopics (49)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (18)

Shuiyun Lan ORCID,Ryan L. Slack ORCID,Zachary C. Lorson ORCID,Andres Emanuelli Castaner ORCID,Rachel Lee ORCID

Live enrichment

PubMed:40479048 PMC:PMC12143351 OpenAlex:https://openalex.org/W4411085917

NIAID NIH HHS

Grant: F31 AI179181

NIAID NIH HHS

Grant: T32 AI106699

NIGMS NIH HHS

Grant: T32 GM008367

NIAID NIH HHS

Grant: R01 AI161570

NCATS NIH HHS

Grant: UL1 TR000454

NIAID NIH HHS

Grant: R01 AI167356

NIAID NIH HHS

Grant: T32 AI157855

NIGMS NIH HHS

Grant: T32 GM135060

NIGMS NIH HHS

Grant: P30 GM133893

National Institutes of Health

Grant: 1F31AI179181-01A1

Multidisciplinary studies on overcoming SARS-CoV-2 main protease drug resistance and on fitness costs

National Institutes of Health

Grant: 1R01AI167356-01A1

Discovery of SARS-CoV-2 antivirals using a replicon assay

National Institutes of Health

Grant: 1F32GM013039-01

MOLECULAR ANALYSIS OF THE YEAST HEAT SHOCK TRANSCRIPTION

National Institutes of Health

Grant: 5T32AI106699-09

Antimicrobial Resistance and Therapeutic Discovery Training Program

National Institutes of Health

Grant: 5R01AI161570-02

Broad-spectrum therapeutics against SARS-CoV-2 3CL protease

National Institutes of Health

Grant: 5UL1TR000454-07

Atlanta Clinical and Translational Science Institute (ACTSI) Renewal

National Institutes of Health

Grant: 5P30GM133893-04

The Center for Biomolecular Structure at NSLS-II

National Institutes of Health

Grant: 5T32GM008367-25

Training Program in Biochemistry, Cell and Molecular Biology

National Institutes of Health

Grant: 1T32AI157855-01A1

Emory Training Program in Translational Research to End the HIV Epidemic

FWCI

8.99

Citation Percentile

1.0%

Citation Trend

2025

2026

goldLicense: cc-by-nc

journalhttps://www.science.org/doi/pdf/10.1126/sciadv.adv8875?download=true

publisherhttps://www.science.org/doi/pdf/10.1126/sciadv.adv8875?download=true

publisherhttps://www.science.org/doi/pdf/10.1126/sciadv.adv8875

journalhttps://doi.org/10.1126/sciadv.adv8875

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40479048

Fields of Study

SARS-CoV-2 and COVID-19 ResearchViral Infections and Immunology ResearchViral gastroenteritis research and epidemiology0301 basic medicine03 medical and health sciences

MeSH Terms

COVID-19SARS-CoV-2Coronavirus 3C ProteasesCOVID-19 Drug TreatmentAntiviral AgentsHumansLactamsLeucineNitrilesProlineSulfonic AcidsViral Nonstructural ProteinsCrystallography, X-RayDrug Resistance, Viral

Keywords

Steric effectsCovalent bondRepliconProteaseChemistrySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)BiologyVirologyStereochemistryEnzymeCoronavirus disease 2019 (COVID-19)BiochemistryPlasmidMedicineGeneLactamsProlineSARS-CoV-2COVID-19Viral Nonstructural ProteinsCrystallography, X-RayAntiviral AgentsCOVID-19 Drug TreatmentLeucineDrug Resistance, ViralNitrilesHumansBiomedicine and Life SciencesSulfonic AcidsCoronavirus 3C Proteases

Sustainable Development Goals

SDG 0: Good health and well-being

Strategy to overcome a nirmatrelvir resistance mechanism in the SARS-CoV-2 nsp5 protease

FAIR Checklist

Authors (18)

Funding (18 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)