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STK11 coordinates IL-4 signaling with metabolic reprogramming to control M2 macrophage polarization and antitumor immunity

Science Advances(2025)10.1126/sciadv.adx5495Source: DataRank Database

STK11 coordinates IL-4 signaling with metabolic reprogramming to control M2 macrophage polarization and antitumor immunity is a research paper published in Science Advances (2025). On theSindex it has a DataRank of 0. It has been cited 4 times.

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Open Access4 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (5 grants)Impact (FWCI 1.62)OA: goldTopics (68)IDs (PubMed, PMC, OpenAlex)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (20)

Naresh Singh ORCID,Chengxian Xu ORCID,Dehui Kong ORCID,Samantha Sharma ORCID,Sheng Liu ORCID

Live enrichment

PubMed:41004572 PMC:PMC12466853 OpenAlex:https://openalex.org/W4414538076

NIDDK NIH HHS

Grant: U54 DK106846

National Institutes of Health

Grant: 3P30CA082709-16S3

Indiana University Melvin and Bren Simon Cancer Center Support Grant

National Institutes of Health

Grant: 5U54DK106846-03

Hematopoietic stem and progenitor cell regulation for enhanced clinical efficacy

National Institutes of Health

Grant: 3P30CA023168-35S1

Cancer Center Support Grant (CORE) Renewal

National Institutes of Health

Grant: 5R01AI153255-03

Transcriptional and metabolic regulation of Treg cell specification for the control of allergic airway disease

FWCI

1.62

Citation Percentile

0.8%

Citation Trend

2025

2026

goldLicense: cc-by-nc

journalhttps://www.science.org/doi/pdf/10.1126/sciadv.adx5495?download=true

publisherhttps://www.science.org/doi/pdf/10.1126/sciadv.adx5495?download=true

publisherhttps://www.science.org/doi/pdf/10.1126/sciadv.adx5495

journalhttps://doi.org/10.1126/sciadv.adx5495

repositoryhttps://pubmed.ncbi.nlm.nih.gov/41004572

Fields of Study

Immune cells in cancerPancreatic and Hepatic Oncology ResearchEpigenetics and DNA Methylation0301 basic medicine03 medical and health sciencesAnimalsInterleukin-4MiceSignal TransductionHumansMacrophagesProtein Serine-Threonine KinasesPancreatic NeoplasmsMacrophage ActivationAMP-Activated Protein Kinase KinasesCarcinoma, Pancreatic DuctalTumor-Associated MacrophagesGlutamineCell PolarityCell Line, TumorMice, KnockoutAMP-Activated Protein KinasesMetabolic Reprogramming

MeSH Terms

Tumor-Associated MacrophagesAMP-Activated Protein Kinase KinasesMetabolic ReprogrammingAnimalsGlutamineHumansMacrophage ActivationMacrophagesPancreatic NeoplasmsSignal TransductionInterleukin-4Cell PolarityProtein Serine-Threonine KinasesMice, KnockoutCarcinoma, Pancreatic DuctalCell Line, TumorMiceAMP-Activated Protein Kinases

Keywords

Macrophage polarizationReprogrammingSTK11TranscriptomeDownregulation and upregulationFOXO1MacrophageGlutaminolysisMice, KnockoutMetabolic ReprogrammingMacrophagesGlutamineCell PolarityProtein Serine-Threonine KinasesMacrophage ActivationAMP-Activated Protein KinasesPancreatic NeoplasmsMiceAMP-Activated Protein Kinase KinasesCell Line, TumorTumor-Associated MacrophagesAnimalsHumansBiomedicine and Life SciencesInterleukin-4Signal TransductionCarcinoma, Pancreatic Ductal