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Structural basis of second-generation HIV integrase inhibitor action and viral resistance

Science(2020)10.1126/science.aay4919Source: DataRank Database

Structural basis of second-generation HIV integrase inhibitor action and viral resistance is a research paper published in Science (2020). On theSindex it has a DataRank of 0. It has been cited 107 times.

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Open Access107 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (16 grants)OA: bronzeTopics (67)IDs (PubMed, PMC)Annotations (1)SDGs (1)

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Findable (1/2)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (10)

Wen Li ORCID,Denes Berta ORCID,Magd Badaoui ORCID,Allison Ballandras-Colas ORCID,Andrea Nans ORCID

Live enrichment

PubMed:32001525 PMC:PMC7023979

National Institutes of Health

Grant: AI150481

National Institutes of Health

Grant: AI070042

Francis Crick Institute

Grant: FC001061

Engineering and Physical Sciences Research Council

Grant: EP/R013012/1

Novel Enhanced Sampling Methods in Multiscale Modeling

European Research Council

Grant: 757850 BioNet

European Research Council

Grant: 757850

Dynamical Redesign of Biomolecular Networks

The Francis Crick Institute

Grant: 10061

Engineering and Physical Sciences Research Council

Grant: EP/R029407/1

The UK High-End Computing Consortium for Biomolecular Simulation

The Francis Crick Institute

Grant: 10015

Engineering and Physical Sciences Research Council

Grant: EP/L000253/1

NIAID NIH HHS

Grant: R01 AI070042

Engineering and Physical Sciences Research Council

Grant: EP/M022609/1

NIAID NIH HHS

Grant: P50 AI150481

Wellcome Trust

Grant: unidentified

unidentified

National Institutes of Health

Grant: 5R01AI070042-08

HIV-1 Integrase Structural Biology

National Institutes of Health

Grant: 3P50AI150481-13S1

MicroCal PEAQ-DSC

bronze

publisherhttps://syndication.highwire.org/content/doi/10.1126/science.aay4919

publisherhttps://www.science.org/doi/pdf/10.1126/science.aay4919

https://doi.org/10.1126/science.aay4919

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023979

https://pubmed.ncbi.nlm.nih.gov/32001525

Fields of Study

0301 basic medicine03 medical and health sciences0303 health sciences

MeSH Terms

HumansMagnesiumAmidesOxazinesPiperazinesPyridonesHeterocyclic Compounds, 3-RingHIV IntegraseGlutamineHistidineSerineGlycineHIV Integrase InhibitorsCryoelectron MicroscopyAmino Acid SubstitutionDrug Resistance, ViralCatalytic DomainMutationHeterocyclic Compounds, 4 or More RingsSingle Molecule ImagingDolutegravir

Keywords

DOLUTEGRAVIR570PyridonesGlutamineDrug ResistanceGlycine610HIV IntegraseCRYO-EM3-RingHeterocyclic Compounds, 4 or More RingsPiperazinesHeterocyclic CompoundsCatalytic Domain616Drug Resistance, ViralOxazinesSerineHumansRECONSTRUCTIONHistidineMagnesiumViralHIV Integrase InhibitorsWILD-TYPEBASIS-SETSScience & TechnologyGAUSSIAN-TYPE BASISCryoelectron MicroscopyDISSOCIATION4 or More Rings540AmidesSingle Molecule ImagingMultidisciplinary SciencesMOLECULAR-ORBITAL METHODSMODEL[SDV] Life Sciences [q-bio]Amino Acid SubstitutionDENSITYMutationScience & Technology - Other TopicsHeterocyclic Compounds, 3-Ring

Sustainable Development Goals

SDG 3: 3. Good health