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Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling

Science(2021)10.1126/science.aba1786Source: DataRank Database

Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling is a research paper published in Science (2021). On theSindex it has a DataRank of 0. It has been cited 607 times.

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0DataRank · unranked

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Open Access607 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (26 grants)Impact (FWCI 34.76)OA: greenTopics (95)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (26)

Kevin R. Parker ORCID,Elena Sotillo ORCID,Rachel C. Lynn ORCID,Hima Anbunathan ORCID,John Lattin ORCID

Live enrichment

PubMed:33795428 PMC:PMC8049103 OpenAlex:https://openalex.org/W3150736119

National Science Foundation

Grant: DGE-1656518

National Institutes of Health

Grant: CA232568-01

National Institutes of Health

Grant: RM1-007735

National Institutes of Health

Grant: K08CA230188

National Institute of Allergy and Infectious Diseases

Grant: AI07290

Teikyo University School of Medicine

Grant: U54 CA232568-01

Stand Up To Cancer

Grant: SU2CAACR-DT1113

Parker Institute for Cancer Immunotherapy

Grant: Bridge Scholar

Burroughs Wellcome Fund

Grant: Career Award for Medical Scientists

Stanford University

Grant: Graduate Fellowship

Germanischer Lloyd

Grant: FMC63

Teikyo University School of Medicine

Grant: 5 T32 AI07290

Human Vaccines Project

Grant: Michelson Prize for Human Immunology and Vaccine Research

NCI NIH HHS

Grant: P01 CA217959

NCI NIH HHS

Grant: U01 CA260852

NCI NIH HHS

Grant: U54 CA232568

NIAID NIH HHS

Grant: T32 AI007290

National Institutes of Health

Grant: 3U54CA232568-01S4

Discovery and Development of Optimal Immunotherapeutic Strategies for Childhood Cancers

National Institutes of Health

Grant: 5K08CA230188-03

Single cell epigenomics in cancer immunity and immunotherapy

National Institutes of Health

Grant: 5T32AI007290-27

Molecular and Cellular Immunobiology

Parker Institute for Cancer Immunotherapy

Stanford University School of Medicine

Teikyo University School of Medicine

Virginia and D.K. Ludwig Fund for Cancer Research

FUNDING

Howard Hughes Medical Institute

FWCI

34.76

Citation Percentile

1.0%

Citation Trend

2020

2021

2022

2023

2024

2025

2026

greenLicense: cc-by

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/8049103

publisherhttps://syndication.highwire.org/content/doi/10.1126/science.aba1786

publisherhttps://www.science.org/doi/pdf/10.1126/science.aba1786

journalhttps://doi.org/10.1126/science.aba1786

Fields of Study

CAR-T cell therapy researchImmune Cell Function and InteractionImmunotherapy and Immune Responses03 medical and health sciences0302 clinical medicineAnimalsCell Line, TumorCytotoxicity, ImmunologicDasatinibDown-RegulationEnhancer of Zeste Homolog 2 ProteinEpigenesis, GeneticEpigenomeFemaleHepatocyte Nuclear Factor 1-alphaHigh Mobility Group ProteinsHumansImmunologic MemoryImmunotherapy, AdoptiveLymphocyte ActivationLymphoid Enhancer-Binding Factor 1MaleMiceNeoplasms, ExperimentalProtein DomainsProtein StabilityReceptors, Chimeric AntigenSignal TransductionT-LymphocytesTranscription, GeneticXenograft Model Antitumor Assays

MeSH Terms

DasatinibEnhancer of Zeste Homolog 2 ProteinProtein DomainsReceptors, Chimeric AntigenEpigenomeAnimalsCytotoxicity, ImmunologicFemaleHigh Mobility Group ProteinsHumansImmunologic MemoryLymphocyte ActivationMaleNeoplasms, ExperimentalT-LymphocytesTranscription, GeneticSignal TransductionDown-RegulationImmunotherapy, AdoptiveXenograft Model Antitumor AssaysEpigenesis, GeneticCell Line, TumorMiceHepatocyte Nuclear Factor 1-alphaLymphoid Enhancer-Binding Factor 1Protein Stability

Keywords

Rest (music)Chimeric antigen receptorEpigeneticsDasatinibBed restImmunotherapyCancer researchPhenotypeEpigenomicsSuppressorImmunologyBiologyMedicineCancerInternal medicineImmune systemDNA methylationGeneticsCytotoxicity, ImmunologicMaleLymphoid Enhancer-Binding Factor 1High Mobility Group ProteinsDown-RegulationNeoplasms, ExperimentalLymphocyte ActivationImmunotherapy, AdoptiveArticleEpigenesis, GeneticEpigenomeMiceProtein DomainsCell Line, TumorAnimalsHumansEnhancer of Zeste Homolog 2 ProteinFemaleHepatocyte Nuclear Factor 1-alphaImmunologic Memory

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being