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Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape

Science(2021)10.1126/science.abe6230Source: DataRank Database

Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape is a research paper published in Science (2021). On theSindex it has a DataRank of 0. It has been cited 448 times.

N/A

0DataRank · unranked

Scored on demand from live citation data

Open Access448 citations

Cite:

Linked data & code

cellosaurus gen pdb

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (24 grants)OA: hybridTopics (47)IDs (PubMed, PMC)Annotations (3)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (30)

Hrishikesh Das ORCID,Hejun Liu,Beate M. Kümmerer ORCID,Florian N. Gohr ORCID,Lea‐Marie Jenster ORCID

Live enrichment

PubMed:33436526 PMC:PMC7932109

Bill and Melinda Gates Foundation

Grant: OPP1170236

Baden-Württemberg Stiftung

Grant: BWST_WSF-022

Horizon 2020 Framework Programme

Grant: CoroNAb

Deutsche Forschungsgemeinschaft

Grant: SFB1403-414786233

Deutsche Forschungsgemeinschaft

Grant: Germany’s Excellence Strategy – EXC2151 – 390873048

Deutsche Forschungsgemeinschaft

Grant: GE 976/9-2

Deutsche Forschungsgemeinschaft

Grant: SPP1923-429513120

Deutsche Forschungsgemeinschaft

Grant: SCHI1073

Deutsche Forschungsgemeinschaft

Grant: TRR237-369799452

Deutsche Forschungsgemeinschaft

Grant: 322568668 (Emmy Noether Programme)

Deutsche Forschungsgemeinschaft

Grant: GRK2168-272482170

Vetenskapsrådet

Grant: 2017-6702

Vetenskapsrådet

Grant: 2018-3808

Ministerium für Wissenschaft, Forschung und Kunst Baden-Württemberg

Grant: 33-7533-6-21/9/1

Klaus Tschira Stiftung

Grant: KT07

Bundesministerium für Bildung und Forschung

Grant: TTU 01.806

NIGMS NIH HHS

Grant: P41 GM103393

European Commission

Grant: 101003653

Nanobodies and antibodies against 2019-nCoV

Knut and Alice Wallenberg Foundation

Grant: unidentified

unidentified

National Institutes of Health

Grant: 5F32GM012006-03

MOLECULAR GENETIC ANALYSIS OF THE DROSOPHILA 205K MAP

National Institutes of Health

Grant: 8P41GM103393-33

A Synchroton Radiation Structural Biology Resource

University of Illinois at Urbana-Champaign

Knut och Alice Wallenbergs Stiftelse

Universitätsklinikum Tübingen

hybridLicense: cc-by

publisherhttps://doi.org/10.1126/science.abe6230

publisherhttps://syndication.highwire.org/content/doi/10.1126/science.abe6230

publisherhttps://www.science.org/doi/pdf/10.1126/science.abe6230

repositoryhttps://www.osti.gov/servlets/purl/1766160

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/7932109

Fields of Study

0301 basic medicine03 medical and health sciences

MeSH Terms

Cell LineAnimalsHumansAntibodies, ViralBinding Sites, AntibodyAntigens, ViralEpitopesCryoelectron MicroscopyAmino Acid SubstitutionVirus ReplicationMembrane FusionAntibody AffinityProtein ConformationProtein BindingMutationAntibodies, NeutralizingSingle-Domain AntibodiesSpike Glycoprotein, CoronavirusProtein DomainsCOVID-19Angiotensin-Converting Enzyme 2SARS-CoV-2Receptors, Coronavirus

Keywords

Protein ConformationAntibody AffinityAntibodies, ViralMembrane FusionCell LineEpitopesProtein DomainsAnimalsHumansAntigens, ViralResearch ArticlesMultidisciplinarySARS-CoV-2Cryoelectron MicroscopyCOVID-19Antibodies, NeutralizingAmino Acid SubstitutionMutationAngiotensin-Converting Enzyme 2Binding Sites, AntibodyProtein BindingReceptors, Coronavirus

Sustainable Development Goals

SDG 3: 3. Good healthSDG 14: 14. Life underwater