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Structure of the human Mediator-bound transcription preinitiation complex

Science(2021)10.1126/science.abg3074Source: DataRank Database

Structure of the human Mediator-bound transcription preinitiation complex is a research paper published in Science (2021). On theSindex it has a DataRank of 0. It has been cited 163 times.

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Open Access163 citations

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Enrichment:Funding (23 grants)Impact (FWCI 9.25)OA: greenTopics (67)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (6)

Anna Talyzina ORCID,Siyu Chen ORCID,Carla Inouye ORCID,Robert Tjian ORCID,Yuan He ORCID

Live enrichment

PubMed:33707221 PMC:PMC8117670 OpenAlex:https://openalex.org/W3135715560

National Institutes of Health

Grant: 1S10OD026963-01

Acquisition of Amersham Typhoon 5 Variable-mode Imager

National Institutes of Health

Grant: U24GM129547

American Cancer Society

Grant: IRG-15-173-21

National Cancer Institute

Grant: P01-CA092584

Oregon Health and Science University

Grant: 436923.9

National Cancer Institute

Grant: CCSG P30 CA060553

National Institute of General Medical Sciences

Grant: T32-GM008382

Chicago Biomedical Consortium

Grant: Catalyst Award

National Cancer Institute

Grant: U54-CA193419

National Institute of General Medical Sciences

Grant: R01-GM135651

NCI NIH HHS

Grant: P30 CA060553

NIGMS NIH HHS

Grant: R01 GM135651

NCI NIH HHS

Grant: U54 CA193419

NIGMS NIH HHS

Grant: T32 GM008382

NIH HHS

Grant: S10 OD026963

NCI NIH HHS

Grant: P01 CA092584

National Institutes of Health

Grant: 3P01CA092584-19S1

Structural Cell Biology of DNA Repair Machines

National Institutes of Health

Grant: 5T32GM008382-21

Molecular Biophysics Training Program at Northwestern University

National Institutes of Health

Grant: 5R01GM135651-03

Structure and Mechanism of Non-Homologous End Joining

National Institutes of Health

Grant: 5U24GM129547-03

Pacific Northwest Center for Cryo-EM

National Institutes of Health

Grant: 5P30CA060553-12

The Robert H.Lurie Comprehensive Cancer Center

National Institutes of Health

Grant: 3U54CA193419-05S1

Spatio-Temporal Organization of Chromatin and Information Transfer in Cancer

Howard Hughes Medical Institute

FWCI

9.25

Citation Percentile

1.0%

Influential Citations

Citation Trend

2021

2022

2023

2024

2025

2026

green

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/8117670

GREENhttps://www.ncbi.nlm.nih.gov/pmc/articles/8117670

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/8117670

publisherhttps://syndication.highwire.org/content/doi/10.1126/science.abg3074

publisherhttps://www.science.org/doi/pdf/10.1126/science.abg3074

Fields of Study

RNA Research and SplicingRNA modifications and cancerRNA and protein synthesis mechanismsMedicineBiology0301 basic medicine03 medical and health sciences0303 health sciences

MeSH Terms

Protein DomainsCyclin-Dependent Kinase-Activating KinaseBinding SitesHumansModels, MolecularPhosphorylationProtein BindingRNA Polymerase IICyclin-Dependent KinasesCatalytic DomainCryoelectron MicroscopyProtein SubunitsTranscription Factors, GeneralTranscription Factor TFIIHMediator ComplexTranscription Initiation, Genetic

Keywords

Transcription preinitiation complexMediatorTranscription factor II FTranscription factor II ERNA polymerase IIRNA polymerase II holoenzymeEukaryotic transcriptionTranscription factor II DCell biologyGeneral transcription factorTranscription (linguistics)Transcription factor II ABiologyGeneComputational biologyGeneticsRNAPromoterGene expressionRNA polymeraseModels, MolecularGeneral Science & TechnologyGeneticProtein DomainsModelsCatalytic DomainHumansPhosphorylationGeneralTranscription Initiation, GeneticBinding SitesMediator ComplexCryoelectron MicroscopyMolecularCyclin-Dependent KinasesProtein SubunitsGeneric health relevanceTranscription Factors, GeneralTranscription Factor TFIIHTranscription InitiationCyclin-Dependent Kinase-Activating KinaseTranscription FactorsProtein Binding

Sustainable Development Goals

SDG 10: 10. No inequality

Structure of the human Mediator-bound transcription preinitiation complex

FAIR Checklist

Authors (6)

Funding (23 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)