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Structure-based discovery of nonopioid analgesics acting through the α 2A -adrenergic receptor

Science(2022)10.1126/science.abn7065Source: DataRank Database

Structure-based discovery of nonopioid analgesics acting through the α 2A -adrenergic receptor is a research paper published in Science (2022). On theSindex it has a DataRank of 0. It has been cited 154 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access154 citations

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Linked data & code

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (4 grants)Impact (FWCI 10.20)OA: greenTopics (41)IDs (PubMed, PMC, OpenAlex)Annotations (3)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (24)

Jun Xu ORCID,Harald Hübner ORCID,João M. Bráz ORCID,Philipp Seemann ORCID,Charlotte Avet

Live enrichment

PubMed:36173843 PMC:PMC10360211 OpenAlex:https://openalex.org/W4297995910

NIGMS NIH HHS

Grant: R01 GM133836

NIGMS NIH HHS

Grant: R35 GM122481

NINDS NIH HHS

Grant: R35 NS097306

NIGMS NIH HHS

Grant: T32 GM008284

FWCI

10.20

Citation Percentile

1.0%

Citation Trend

2022

2023

2024

2025

2026

green

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC10360211/pdf/nihms-1863177.pdf

publisherhttps://www.science.org/doi/pdf/10.1126/science.abn7065

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/10360211

journalhttps://doi.org/10.1126/science.abn7065

Fields of Study

Receptor Mechanisms and SignalingComputational Drug Discovery MethodsPharmacogenetics and Drug MetabolismAdrenergic alpha-2 Receptor AgonistsAnalgesics, Non-NarcoticAnimalsDexmedetomidineDrug DesignDrug DiscoveryHumansLigandsMiceMolecular Docking SimulationPainPain ManagementStructure-Activity Relationship

MeSH Terms

AnimalsHumansLigandsPainStructure-Activity RelationshipDrug DesignAnalgesics, Non-NarcoticDexmedetomidineMiceDrug DiscoveryAdrenergic alpha-2 Receptor AgonistsPain ManagementMolecular Docking Simulation

Keywords

AdrenergicVirtual screeningChemistryAdrenergic receptorPharmacologyReceptorComputational biologyBioinformaticsMedicineDrug discoveryBiologyBiochemistry

Sustainable Development Goals

SDG 0: Good health and well-being