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NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT

Science(2025)10.1126/science.adx9717Source: DataRank Database

NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT is a research paper published in Science (2025). On theSindex it has a DataRank of 0. It has been cited 6 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access6 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (27 grants)Impact (FWCI 2.50)OA: hybridTopics (32)IDs (PubMed, PMC, OpenAlex)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (27)

Phong Nguyen ORCID,Varun Sondhi ORCID,Run-Wen Yao ORCID,Zhifang Lu ORCID,Tao Dai ORCID

Live enrichment

PubMed:41196949 PMC:PMC12853130 OpenAlex:https://openalex.org/W4415970831

National Institutes of Health

Grant: P50CA196516

National Institutes of Health

Grant: KL2TR003981

National Institutes of Health

Grant: CTSA-PP-YR1-D-009

National Institutes of Health

Grant: R35CA220449

National Institutes of Health

Grant: P50CA070907

National Institutes of Health

Grant: K99GM151439

National Institutes of Health

Grant: R35GM138157

National Institutes of Health

Grant: T32CA291654

Institutional Research Grant under American Cancer Society

Grant: IRG-21-1542-16

National Institutes of Health

Grant: P30CA142543

National Institutes of Health

Grant: R01CA285336

National Institutes of Health

Grant: 1K99GM154116

Cancer Prevention and Research Institute of Texas

Grant: RP240494

National Institutes of Health

Grant: 1R35GM160468-01

Harnessing the Power of Data and Artificial Intelligence to Resolve the Human 3D Interactome

National Institutes of Health

Grant: 5K99AI180984-02

Functions of Rapidly-Evolving Proteins and Their Roles in Pathogenicity

National Institutes of Health

Grant: 1T32CA291654-01

Translational Cancer Biology (TCB) T32 Training Program

NIAID NIH HHS

Grant: K99 AI180984

NIGMS NIH HHS

Grant: R35 GM160468

NIGMS NIH HHS

Grant: K99 GM154116

Startup Award from UT Southwestern Department of Radiation Oncology

Howard Hughes Medical Institute Investigator Program

Lung SPORE Career Enhancement Award

Howard Hughes Medical Institute

Eugene McDermott Endowment for the Study of Human Growth and Development

The Moody Foundation

Distinguished Research Award from the President’s Research Council

Howard Hughes Medical Institute

FWCI

2.50

Citation Percentile

0.9%

Citation Trend

2026

hybridLicense: cc-by

journalhttps://doi.org/10.1126/science.adx9717

publisherhttps://doi.org/10.1126/science.adx9717

publisherhttps://www.science.org/doi/pdf/10.1126/science.adx9717

repositoryhttps://pubmed.ncbi.nlm.nih.gov/41196949

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/12853130

Fields of Study

Biochemical and Molecular ResearchHIV/AIDS drug development and treatmentPolyamine Metabolism and Applications0301 basic medicine03 medical and health sciencesHumansHEK293 CellsProtein MultimerizationPurinesPyrophosphatasesSulfhydryl Compounds

MeSH Terms

HumansPurinesPyrophosphatasesSulfhydryl CompoundsProtein MultimerizationHEK293 Cells

Keywords

PurineNucleotide salvagePurine metabolismNucleotideThiopurine methyltransferaseGlutamine amidotransferaseDe novo synthesisEnzymeHEK293 CellsPurinesHumansSulfhydryl CompoundsProtein MultimerizationPyrophosphatasesArticle