Pilot corpus: NIH-funded biomedical datasets. Any DOI can be scored on demand — network effects sharpen as coverage grows.

Heterozygous OAS1 gain-of-function variants cause an autoinflammatory immunodeficiency

Science Immunology(2021)10.1126/sciimmunol.abf9564Source: DataRank Database

Heterozygous OAS1 gain-of-function variants cause an autoinflammatory immunodeficiency is a research paper published in Science Immunology (2021). On theSindex it has a DataRank of 0. It has been cited 70 times.

N/A

0DataRank · unranked

Scored on demand from live citation data

Open Access70 citations

Download PDF

Cite:

Linked data & code

pdb

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (27 grants)Impact (FWCI 3.59)OA: greenTopics (75)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

FAIR checklist signals are shown for context only and do not affect DataRank scoring.

Run a calibrated FAIR evaluation for this paper →

We only score data papers we can read in full — never from an abstract alone.

Authors (28)

Tsubasa Okano ORCID,Lars M. Koenig,Daniel F. R. Boehmer ORCID,Samantha L. Schwartz ORCID,Kento Inoue ORCID

Live enrichment

PubMed:34145065 PMC:PMC8392508 OpenAlex:https://openalex.org/W3166909172

National Institutes of Health

Grant: R01-AI144067

National Institutes of Health

Grant: T32-GM008367

National Institutes of Health

Grant: F31-AI133950

Cystic Fibrosis Foundation

Grant: DEY18F0

Care-for-Rare Foundation

Grant: 160073

Deutsche Forschungsgemeinschaft

Grant: 315563603

German Centre for Infection Research

Grant: TTU 07.909

German Federal Ministry of Education and Research

Grant: 01GM1910C

Else Kröner-Fresenius Stiftung

Grant: 2017_A110

Friedrich-Baur-Stiftung

Grant: 48/17

Else Kröner-Fresenius Stiftung

Grant: 2017_A50

Japan Society for the Promotion of Science

Grant: 19K23861

JSPS Grant-in-Aid for Scientific Research

Grant: 20K16847

BMBF for the chILD-EU register and biobank project

Grant: HCQ4S

Health and Labor Science Research Grant

Grant: 201911006B

Health and Labor Science Research Grant

Grant: 201911013B

JSPS Grant-in-Aid for Scientific Research

Grant: 26293244

JSPS Grant-in-Aid for Scientific Research

Grant: 18H02778

European Reference Network for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases

Grant: 739543

ERA-Net for Research on Rare Diseases and the European Cooperation in Science and Technology

Grant: COST A16125

AMED Rare/Intractable Disease Project

Grant: 1010139

NIAID NIH HHS

Grant: F31 AI133950

NIGMS NIH HHS

Grant: T32 GM008367

NIAID NIH HHS

Grant: R01 AI144067

National Institutes of Health

Grant: 5R01AI144067-06

dsRNA regulation of the cytosolic innate immune system

National Institutes of Health

Grant: 5F31AI133950-02

Regulation of 2'-5'-oligoadenylate synthetase 1 (OAS1) by dsRNA

Deutsche Forschungsgemeinschaft

Grant: unidentified

unidentified

FWCI

3.59

Citation Percentile

0.9%

Citation Trend

2021

2022

2023

2024

2025

2026

green

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/8392508

publisherhttps://syndication.highwire.org/content/doi/10.1126/sciimmunol.abf9564

publisherhttps://www.science.org/doi/pdf/10.1126/sciimmunol.abf9564

journalhttps://doi.org/10.1126/sciimmunol.abf9564

Fields of Study

interferon and immune responsesRNA regulation and diseaseViral Infections and Immunology Research0301 basic medicine03 medical and health sciences2',5'-Oligoadenylate SynthetaseB-LymphocytesCells, CulturedDNA Mutational AnalysisEndoribonucleasesEnzyme AssaysGain of Function MutationGene Knockout TechniquesHematopoietic Stem Cell TransplantationHereditary Autoinflammatory DiseasesHeterozygoteHumansInfantInfant, NewbornInterferon Type IMacrophagesMolecular Dynamics SimulationMonocytesPrimary Cell CulturePrimary Immunodeficiency DiseasesRecombinant ProteinsSignal Transduction

MeSH Terms

Gain of Function MutationPrimary Immunodeficiency DiseasesB-LymphocytesCells, CulturedDNA Mutational AnalysisEndoribonucleasesHeterozygoteHumansInfantInfant, NewbornInterferon Type IMacrophagesMonocytesRecombinant Proteins2',5'-Oligoadenylate SynthetaseSignal TransductionHematopoietic Stem Cell TransplantationGene Knockout TechniquesMolecular Dynamics SimulationHereditary Autoinflammatory DiseasesEnzyme AssaysPrimary Cell Culture

Keywords

BiologyInterferonImmunologyChronic granulomatous diseaseB-LymphocytesHeterozygote2',5'-Oligoadenylate Synthetase; B-Lymphocytes; Cells, Cultured; DNA Mutational Analysis; Endoribonucleases; Enzyme Assays; Gain of Function Mutation; Gene Knockout Techniques; Hematopoietic Stem Cell Transplantation; Hereditary Autoinflammatory Diseases; Heterozygote; Humans; Infant; Infant, Newborn; Interferon Type I; Macrophages; Molecular Dynamics Simulation; Monocytes; Primary Cell Culture; Primary Immunodeficiency Diseases; Recombinant Proteins; Signal TransductionMacrophagesPrimary Immunodeficiency DiseasesDNA Mutational AnalysisHereditary Autoinflammatory DiseasesPrimary Cell CultureHematopoietic Stem Cell TransplantationInfant, Newborn610InfantMolecular Dynamics SimulationMonocytesGene Knockout TechniquesGain of Function MutationEndoribonucleasesInterferon Type I2',5'-Oligoadenylate SynthetaseHumansCells, CulturedEnzyme Assays

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

Heterozygous OAS1 gain-of-function variants cause an autoinflammatory immunodeficiency

FAIR Checklist

Authors (28)

Funding (27 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)