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Activation of mTORC1 at late endosomes misdirects T cell fate decision in older individuals

Science Immunology(2021)10.1126/sciimmunol.abg0791Source: DataRank Database

Activation of mTORC1 at late endosomes misdirects T cell fate decision in older individuals is a research paper published in Science Immunology (2021). On theSindex it has a DataRank of 0. It has been cited 48 times.

N/A

0DataRank · unranked

Scored on demand from live citation data

Open Access48 citations

Cite:

Linked data & code

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (19 grants)Impact (FWCI 2.13)OA: greenTopics (91)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (3)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (12)

Chulwoo Kim ORCID,Qiong Xia ORCID,Timothy Gould ORCID,Wenqiang Cao ORCID,Huimin Zhang ORCID

Live enrichment

PubMed:34145066 PMC:PMC8422387 OpenAlex:https://openalex.org/W3167068364

National Institutes of Health

Grant: R01 AR042527

National Institutes of Health

Grant: R01 HL117913

National Institutes of Health

Grant: R01 HL142068

National Institutes of Health

Grant: P01 HL129941

National Institutes of Health

Grant: HHSN272201300006C

National Institute on Aging

Grant: R01 AG045779

National Institute of Allergy and Infectious Diseases

Grant: U19 AI057266

National Institute of Allergy and Infectious Diseases

Grant: R01 AI108906

National Institute of Allergy and Infectious Diseases

Grant: R01 AI108891

National Institute of Allergy and Infectious Diseases

Grant: R01 AI129191

National Institute of Allergy and Infectious Diseases

Grant: 75N9301900065

National Institutes of Health

Grant: 5R01HL117913-08

The NOTCH Signaling Pathway in Large Vessel Vasculitis

National Institutes of Health

Grant: 5R01AG045779-03

Influence of Age on CD4 T Memory Cells

National Institutes of Health

Grant: 5R01AI108891-07

microRNA Regulation of T Cell Senescence

National Institutes of Health

Grant: 5R01AR042527-10

Oligoclonal T Cell Expansion &Rheumatoid Arthritis

National Institutes of Health

Grant: 5R01AI108906-10

DNA Repair and Mitochondrial Dysfunction in T Cell Aging

National Institutes of Health

Grant: 3P01HL129941-03S1

The Role of Inflammation in Cardiovascular Disease

National Institutes of Health

Grant: 3U19AI057266-05S1

IMMUNOLOGICAL MEMORY TO VACCINATION

National Institutes of Health

Grant: 5R01HL142068-02

T Cell Immunity in Giant Cell Arteritis

FWCI

2.13

Citation Percentile

0.9%

Citation Trend

2021

2022

2023

2024

2025

2026

green

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/8422387

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/8422387

publisherhttps://syndication.highwire.org/content/doi/10.1126/sciimmunol.abg0791

publisherhttps://www.science.org/doi/pdf/10.1126/sciimmunol.abg0791

journalhttps://doi.org/10.1126/sciimmunol.abg0791

Fields of Study

T-cell and B-cell ImmunologyImmune Cell Function and InteractionMast cells and histamine0301 basic medicine03 medical and health sciencesAdoptive TransferAdultAgedAged, 80 and overAnimalsAutophagy-Related ProteinsBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCOVID-19Cells, CulturedEndosomesFemaleForkhead Box Protein O1Healthy VolunteersHumansLarge Neutral Amino Acid-Transporter 1LysosomesMaleMechanistic Target of Rapamycin Complex 1MiceMice, Inbred C57BLMice, TransgenicSARS-CoV-2Signal TransductionTransfectionVesicular Transport ProteinsYoung Adult

MeSH Terms

Forkhead Box Protein O1Autophagy-Related ProteinsMechanistic Target of Rapamycin Complex 1COVID-19SARS-CoV-2AdultAgedAged, 80 and overAnimalsCells, CulturedFemaleHumansLysosomesMaleMice, Inbred C57BLMice, TransgenicEndosomesTransfectionSignal TransductionCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesAdoptive TransferLarge Neutral Amino Acid-Transporter 1Vesicular Transport ProteinsMiceBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsYoung AdultHealthy Volunteers

Keywords

EndosomemTORC1Cell biologyCellBiologyFunction (biology)Signal transductionIntracellularPI3K/AKT/mTOR pathwayGeneticsAdultAged, 80 and overCD4-Positive T-LymphocytesMaleBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsForkhead Box Protein O1Autophagy-Related ProteinsCOVID-19EndosomesCD8-Positive T-LymphocytesMechanistic Target of Rapamycin Complex 1Adoptive TransferHealthy VolunteersLarge Neutral Amino Acid-Transporter 1AnimalsHumansFemaleLysosomesCells, CulturedAged

Sustainable Development Goals

SDG 3: 3. Good healthSDG 12: 12. Responsible consumptionSDG 0: Good health and well-being

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