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Inducible protein degradation reveals inflammation-dependent function of the T reg cell lineage–defining transcription factor Foxp3

Science Immunology(2025)10.1126/sciimmunol.adr7057Source: DataRank Database

Inducible protein degradation reveals inflammation-dependent function of the T reg cell lineage–defining transcription factor Foxp3 is a research paper published in Science Immunology (2025). On theSindex it has a DataRank of 0.490. It has been cited 15 times, with 14 citing works in its 1-hop citation network.

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0.490DataRank · unranked

Scored on demand from live citation data

15 citations · 14 citing works in its network

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (3 grants)Impact (FWCI 5.66)OA: greenTopics (37)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (0/2)

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 85%Citation Network 15%

Base Score Contribution

0.416

From this paper's citation signal

Citation Network Contribution

0.0737

From 6 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 14 citers.

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Cell202614 citations122 referencesContributes 0.022
Tissue-resident regulatory T cells: modulators of local immunity
Trends in Immunology20264 citations116 referencesContributes 0.014
The history and promise of Treg cells
Immunity20252 citations92 referencesContributes 0.012
Foxp3 drives context-dependent epigenetic programs that define regulatory T cell molecular identity and function
Science Immunology20261 citations80 referencesContributes 0.009

Authors (11)

Polina Dimitrova,Qiong Sun,Jesse Tennebroek,Elisa Marchiori ORCID,Markus Jaritz ORCID

Live enrichment

PubMed:40478934 PMC:PMC7617780 OpenAlex:https://openalex.org/W4411085891

European Research Council

Grant: 101116251

Deconstructing Intestinal Immune Tolerance

European Research Council

Grant: 101125797

Unlocking a T cell-mediated Immune response in therapy-challenged Tumors

European Commission

Grant: 955951

Deconstructing the evolution of metastasis

FWCI

5.66

Citation Percentile

1.0%

Citation Trend

2025

2026

greenLicense: cc-by

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/7617780

publisherhttps://www.science.org/doi/pdf/10.1126/sciimmunol.adr7057

journalhttps://doi.org/10.1126/sciimmunol.adr7057

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40478934

Fields of Study

Immune Cell Function and InteractionT-cell and B-cell ImmunologyImmunotherapy and Immune Responses03 medical and health sciences0302 clinical medicine

MeSH Terms

AnimalsInflammationMice, Inbred C57BLMice, KnockoutCell LineageT-Lymphocytes, RegulatoryMiceForkhead Transcription FactorsProteolysis

Keywords

FOXP3InflammationBiologyTranscription factorImmune systemCell biologyAutoimmunityCancer researchImmunologyT cellRegulatory T cellIL-2 receptorGeneGeneticsMice, Inbred C57BLMice, KnockoutMiceProteolysisAnimalsForkhead Transcription FactorsCell LineageT-Lymphocytes, RegulatoryArticle

Sustainable Development Goals

SDG 0: Good health and well-being