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Poly-GR repeats associated with ALS/FTD gene C9ORF72 impair translation elongation and induce a ribotoxic stress response in neurons

Science Signaling(2024)10.1126/scisignal.adl1030Source: DataRank Database

Poly-GR repeats associated with ALS/FTD gene C9ORF72 impair translation elongation and induce a ribotoxic stress response in neurons is a research paper published in Science Signaling (2024). On theSindex it has a DataRank of 0. It has been cited 18 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access18 citations

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Linked data & code

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (7 grants)Impact (FWCI 5.59)OA: greenTopics (29)IDs (PubMed, PMC, OpenAlex)Annotations (3)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (11)

Zhe Zhang ORCID,Yini Li ORCID,Malgorzata J. Latallo ORCID,Shaopeng Wang ORCID,B.Dean Nelson ORCID

Live enrichment

PubMed:39106320 PMC:PMC11466505 OpenAlex:https://openalex.org/W4401357681

NINDS NIH HHS

Grant: R37 NS057553

NINDS NIH HHS

Grant: RF1 NS101986

NINDS NIH HHS

Grant: RF1 NS113820

NINDS NIH HHS

Grant: RF1 NS127925

NIA NIH HHS

Grant: R21 AG072078

NIGMS NIH HHS

Grant: T32 GM008403

NINDS NIH HHS

Grant: R01 NS107347

FWCI

5.59

Citation Percentile

1.0%

Citation Trend

2025

2026

green

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC11466505/pdf/nihms-2022705.pdf

publisherhttps://www.science.org/doi/pdf/10.1126/scisignal.adl1030

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/11466505

journalhttps://doi.org/10.1126/scisignal.adl1030

Fields of Study

Amyotrophic Lateral Sclerosis Researchbiodegradable polymer synthesis and propertiesParkinson's Disease Mechanisms and Treatments

MeSH Terms

C9orf72 ProteinAmyotrophic Lateral SclerosisHumansNeuronsPeptide Chain Elongation, TranslationalRibosomesStress, PhysiologicalDNA Repeat Expansionp38 Mitogen-Activated Protein KinasesInduced Pluripotent Stem CellsFrontotemporal Dementia

Keywords

C9orf72NeuroprotectionTranslation (biology)Trinucleotide repeat expansionNeurodegenerationCell biologyBiologyAmyotrophic lateral sclerosisChemistryGeneBiochemistryNeuroscienceMedicineMessenger RNAInternal medicine

Sustainable Development Goals

SDG 0: Zero hunger