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The mechanosensitive channel TRPV4 inhibits pulmonary inflammation by limiting NF-κB signaling in alveolar macrophages

Science Signaling(2025)10.1126/scisignal.adt1539Source: DataRank Database

The mechanosensitive channel TRPV4 inhibits pulmonary inflammation by limiting NF-κB signaling in alveolar macrophages is a research paper published in Science Signaling (2025). On theSindex it has a DataRank of 0. It has been cited 2 times.

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Scored on demand from live citation data

Open Access2 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (12 grants)Impact (FWCI 1.48)OA: greenTopics (24)IDs (PubMed, PMC, OpenAlex)Annotations (4)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (14)

Megan E. Grund ORCID,Y. Wang ORCID,E.M. Orsini ORCID,Yan Liu ORCID,Susamma Abraham

Live enrichment

PubMed:41433421 PMC:PMC12781032 OpenAlex:https://openalex.org/W7116855197

National Institutes of Health

Grant: K08-HL133380

National Institutes of Health

Grant: R01-HL155064

National Institutes of Health

Grant: R01-HL158746

National Institutes of Health

Grant: R01-HL133721

National Institutes of Health

Grant: R35GM149240

National Institutes of Health

Grant: T32HL155005

NHLBI NIH HHS

Grant: R01 HL155064

NHLBI NIH HHS

Grant: K08 HL133380

NHLBI NIH HHS

Grant: R01 HL166544

NHLBI NIH HHS

Grant: R01 HL133721

NHLBI NIH HHS

Grant: R56 HL160639

NHLBI NIH HHS

Grant: R01 HL158746

FWCI

1.48

Citation Percentile

0.8%

Citation Trend

2026

green

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC12781032/

publisherhttps://www.science.org/doi/pdf/10.1126/scisignal.adt1539

journalhttps://doi.org/10.1126/scisignal.adt1539

repositoryhttps://pubmed.ncbi.nlm.nih.gov/41433421

Fields of Study

Ion Channels and ReceptorsBarrier Structure and Function StudiesNF-κB Signaling Pathways

MeSH Terms

AnimalsHumansMice, Inbred C57BLPseudomonas aeruginosaPseudomonas InfectionsSignal TransductionNF-kappa BMacrophages, AlveolarPneumonia, BacterialMechanotransduction, CellularTRPV Cation ChannelsMiceTranscription Factor RelA

Keywords

Proinflammatory cytokineMechanosensitive channelsTRPV4InflammationEndoplasmic reticulumMechanosensationSignal transductionCytoplasm

Sustainable Development Goals

SDG 0: Good health and well-being

The mechanosensitive channel TRPV4 inhibits pulmonary inflammation by limiting NF-κB signaling in alveolar macrophages

FAIR Checklist

Authors (14)

Funding (12 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)