Pilot corpus: NIH-funded biomedical datasets. Any DOI can be scored on demand — network effects sharpen as coverage grows.

Targeting integrated epigenetic and metabolic pathways in lethal childhood PFA ependymomas

Science Translational Medicine(2021)10.1126/scitranslmed.abc0497Source: DataRank Database

Targeting integrated epigenetic and metabolic pathways in lethal childhood PFA ependymomas is a research paper published in Science Translational Medicine (2021). On theSindex it has a DataRank of 1.4. It has been cited 59 times, with 43 citing works in its 1-hop citation network.

N/A

1.4DataRank · unranked

Scored on demand from live citation data

Open Access59 citations · 43 citing works in its network

Download PDF

Cite:

Linked data & code

geo nct

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (18 grants)Impact (FWCI 2.96)OA: greenTopics (58)Linked Datasets (2)DataCite Reuse (2)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (2/2)

Has DOI
Indexed in repositories

Accessible (1/2)

Open Access

Interoperable (2/2)

DataCite relations
Linked datasets

Reusable (0/3)

FAIR checklist signals are shown for context only and do not affect DataRank scoring.

Run a calibrated FAIR evaluation for this paper →

We only score data papers we can read in full — never from an abstract alone.

DataRank Breakdown

Base Score 43%Citation Network 57%

Base Score Contribution

0.614

From this paper's citation signal

Citation Network Contribution

0.828

From 36 citing papers with measurable signal

Learn more about DataRank methodology →

Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 43 citers.

Inhibition of mitochondrial bioenergetics and hypoxia to radiosensitize diffuse intrinsic pontine glioma
Neuro-Oncology202415 citations35 referencesContributes 0.079
The Emerging Relevance of H3K27 Trimethylation Loss in Meningioma: A Systematic Review of Recurrence and Overall Survival with Meta-Analysis
World Neurosurgery202210 citations32 referencesContributes 0.075
A Parental Request for an Unproven Treatment for a Rare Pediatric Cancer: Sound Reasons for Not Going Off‐Label
The Hastings Center Report20261 citations11 referencesContributes 0.063
Delineation of molecular characteristics in pediatric PFA ependymoma involving rare osseous and pulmonary metastases: A case report and literature review
Frontiers in Oncology20224 citations32 referencesContributes 0.050
Recent Advancements in Ependymoma: Challenges and Therapeutic Opportunities
Pediatric Neurosurgery20232 citations22 referencesContributes 0.050

Authors (45)

Benita Tamrazi ORCID,Derek Dang ORCID,Chan Chung ORCID,Stefan R. Sweha ORCID,Siva Kumar Natarajan ORCID

Live enrichment

PubMed:34613815 PMC:PMC8762577 OpenAlex:https://openalex.org/W3202968128

Cancer Research UK

Grant: 26398

NCI NIH HHS

Grant: P50 CA097257

NCI NIH HHS

Grant: R01 CA204969

NINDS NIH HHS

Grant: K08 NS099427

NCI NIH HHS

Grant: R01 CA222251

NIGMS NIH HHS

Grant: T32 GM007315

Cancer Research UK

Grant: 22492

NINDS NIH HHS

Grant: R01 NS110572

Cancer Research UK

Grant: 28598

NCI NIH HHS

Grant: R01 CA227622

NCI NIH HHS

Grant: F31 CA260935

NIGMS NIH HHS

Grant: T32 GM007863

National Institutes of Health

Grant: 5K08NS099427-03

Targeting ATRX-Deficient Pediatric GBM

National Institutes of Health

Grant: 5R01CA227622-04

Targeting Stromal Influences on Glutamine Addiction in Ovarian Cancer

National Institutes of Health

Grant: 5R01CA222251-05

Identification of USP13 as a therapeutic target for ovarian cancer

National Institutes of Health

Grant: 5P50CA097257-12

BRAIN TUMOR SPORT GRANT

National Institutes of Health

Grant: 5R01NS110572-05

Unraveling metabolic dependencies in H3K27M mutant Diffuse Intrinsic Pontine Gliomas

National Institutes of Health

Grant: 1R01CA204969-01A1

Uncovering Role of Exosomes in Regulating Pancreatic Cancer Cell Metabolism

FWCI

2.96

Citation Percentile

0.9%

Citation Trend

2021

2022

2023

2024

2025

2026

green

repositoryhttps://escholarship.org/content/qt1kk3z1g3/qt1kk3z1g3.pdf

publisherhttps://www.science.org/doi/pdf/10.1126/scitranslmed.abc0497

repositoryhttps://escholarship.org/uc/item/1kk3z1g3

journalhttps://doi.org/10.1126/scitranslmed.abc0497

Fields of Study

Epigenetics and DNA MethylationHistone Deacetylase Inhibitors ResearchGlioma Diagnosis and Treatment0301 basic medicine03 medical and health sciences0303 health sciences

MeSH Terms

AnimalsChildEpendymomaHistonesHumansEpigenesis, GeneticMiceMetabolic Networks and PathwaysEpigenomics

Keywords

EpigeneticsMetabolic pathwayEpendymomaBiologyCancer researchEpigenesisPosterior fossaMedicineBioinformaticsNeuroscienceComputational biologyGeneticsDNA methylationPathologyGeneAnatomyGene expressionEpigenomicsPediatric CancerMedical Biotechnology610Medical and Health SciencesEpigenesis, GeneticHistonesMiceRare DiseasesGenetic2.1 Biological and endogenous factorsAnimalsHumansChildCancerPediatricBiomedical and Clinical SciencesHuman GenomeNeurosciencesBiological SciencesBrain DisordersBrain CancerOrphan DrugBiomedical engineeringMetabolic Networks and PathwaysBiotechnology

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: No poverty

Additional file 1 of Common molecular features of H3K27M DMGs and PFA ependymomas map to hindbrain developmental pathways

10.6084/m9.figshare.26567579.v1figshare

Additional file 1 of Common molecular features of H3K27M DMGs and PFA ependymomas map to hindbrain developmental pathways

10.6084/m9.figshare.26567579figshare

Targeting integrated epigenetic and metabolic pathways in lethal childhood PFA ependymomas

FAIR Checklist

DataRank Breakdown

Top 5 citers driving the network score

Authors (45)

Funding (18 grants)

Impact

Open Access

Topics

Linked Datasets (2)

Annotations (Europe PMC)