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Ubiquitination and degradation of SUMO1 by small-molecule degraders extends survival of mice with patient-derived tumors

Science Translational Medicine(2021)10.1126/scitranslmed.abh1486Source: DataRank Database

Ubiquitination and degradation of SUMO1 by small-molecule degraders extends survival of mice with patient-derived tumors is a research paper published in Science Translational Medicine (2021). On theSindex it has a DataRank of 0. It has been cited 43 times.

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Open Access43 citations

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Enrichment:Funding (4 grants)Impact (FWCI 2.58)OA: greenTopics (30)Linked Datasets (16)DataCite Reuse (16)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (2)

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Context only (not used in score)

Findable (2/2)

Has DOI
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Accessible (1/2)

Open Access

Interoperable (2/2)

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Reusable (0/3)

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Authors (19)

Hong Ri Jin,Ho‐Yin Lo,Sung Han Jung,Chafiq Hamdouchi ORCID,Dae-Ho Kim ORCID

Live enrichment

PubMed:34644148 PMC:PMC9450956 OpenAlex:https://openalex.org/W3206807389

NCI NIH HHS

Grant: R01 CA203893

NCI NIH HHS

Grant: R43 CA224461

National Institutes of Health

Grant: 5R01CA203893-06

SUMO1 inhibition compound as a new anticancer drug for glioblastoma therapy

National Institutes of Health

Grant: 1R43CA224461-01A1

Development of Small Molecule SUMO1 Inhibitors for Treatment of Glioblastoma

FWCI

2.58

Citation Percentile

0.9%

Citation Trend

2021

2022

2023

2024

2025

2026

greenLicense: public-domain

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/9450956

publisherhttps://www.science.org/doi/pdf/10.1126/scitranslmed.abh1486

journalhttps://doi.org/10.1126/scitranslmed.abh1486

repositoryhttps://pubmed.ncbi.nlm.nih.gov/34644148

Fields of Study

Ubiquitin and proteasome pathwaysProtein Degradation and InhibitorsHistone Deacetylase Inhibitors Research0301 basic medicine03 medical and health sciences

MeSH Terms

AnimalsHumansNeoplasmsSUMO-1 ProteinMiceUbiquitination

Keywords

Ubiquitin ligaseUbiquitinCullinCancer researchSmall moleculeDrug discoveryUbiquitin-Protein LigasesChemistryBiologyNeddylationCell biologyMolecular biologyBiochemistryMiceNeoplasmsSUMO-1 ProteinUbiquitinationAnimalsHumans

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

Additional file 7 of Caprin-1 influences autophagy-induced tumor growth and immune modulation in pancreatic cancer

10.6084/m9.figshare.26652255.v1figshare

Additional file 7 of Caprin-1 influences autophagy-induced tumor growth and immune modulation in pancreatic cancer

10.6084/m9.figshare.26652255figshare

Additional file 6 of Caprin-1 influences autophagy-induced tumor growth and immune modulation in pancreatic cancer

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Additional file 8 of Caprin-1 influences autophagy-induced tumor growth and immune modulation in pancreatic cancer

10.6084/m9.figshare.26652258figshare

Additional file 5 of Caprin-1 influences autophagy-induced tumor growth and immune modulation in pancreatic cancer

10.6084/m9.figshare.26652249.v1figshare

Additional file 6 of Caprin-1 influences autophagy-induced tumor growth and immune modulation in pancreatic cancer

10.6084/m9.figshare.26652252figshare

Additional file 5 of Caprin-1 influences autophagy-induced tumor growth and immune modulation in pancreatic cancer

10.6084/m9.figshare.26652249figshare

Additional file 8 of Caprin-1 influences autophagy-induced tumor growth and immune modulation in pancreatic cancer

10.6084/m9.figshare.26652258.v1figshare

Additional file 3 of Caprin-1 influences autophagy-induced tumor growth and immune modulation in pancreatic cancer

10.6084/m9.figshare.26652243figshare

Additional file 4 of Caprin-1 influences autophagy-induced tumor growth and immune modulation in pancreatic cancer

10.6084/m9.figshare.26652246.v1figshare

Additional file 3 of Caprin-1 influences autophagy-induced tumor growth and immune modulation in pancreatic cancer

10.6084/m9.figshare.26652243.v1figshare

Additional file 1 of Caprin-1 influences autophagy-induced tumor growth and immune modulation in pancreatic cancer

10.6084/m9.figshare.26652237.v1figshare

Additional file 1 of Caprin-1 influences autophagy-induced tumor growth and immune modulation in pancreatic cancer

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Additional file 2 of Caprin-1 influences autophagy-induced tumor growth and immune modulation in pancreatic cancer

10.6084/m9.figshare.26652240.v1figshare

Additional file 4 of Caprin-1 influences autophagy-induced tumor growth and immune modulation in pancreatic cancer

10.6084/m9.figshare.26652246figshare

Additional file 2 of Caprin-1 influences autophagy-induced tumor growth and immune modulation in pancreatic cancer

10.6084/m9.figshare.26652240figshare

Ubiquitination and degradation of SUMO1 by small-molecule degraders extends survival of mice with patient-derived tumors

FAIR Checklist

Authors (19)

Funding (4 grants)

Impact

Open Access

Topics

Linked Datasets (16)

Annotations (Europe PMC)