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The oral nucleoside prodrug GS-5245 is efficacious against SARS-CoV-2 and other endemic, epidemic, and enzootic coronaviruses

Science Translational Medicine(2024)10.1126/scitranslmed.adj4504Source: DataRank Database

The oral nucleoside prodrug GS-5245 is efficacious against SARS-CoV-2 and other endemic, epidemic, and enzootic coronaviruses is a research paper published in Science Translational Medicine (2024). On theSindex it has a DataRank of 0.888. It has been cited 22 times, with 15 citing works in its 1-hop citation network.

N/A

0.888DataRank · unranked

Scored on demand from live citation data

Open Access22 citations · 15 citing works in its network

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Linked data & code

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DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (2 grants)Impact (FWCI 6.58)OA: greenTopics (50)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 53%Citation Network 47%

Base Score Contribution

0.470

From this paper's citation signal

Citation Network Contribution

0.418

From 7 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 15 citers.

Oral pharmacokinetics and efficacy of oral phospholipid remdesivir nucleoside prodrugs against SARS-CoV-2 in mice
Antimicrobial Agents and Chemotherapy20246 citations13 referencesContributes 0.150
Broad‐Spectrum Antiviral Activity of the Orally Bioavailable Antiviral ATV014 Against Multiple Coronaviruses
MedComm20251 citations5 referencesContributes 0.139
Clinical Evaluation of Drug–Drug Interactions with Obeldesivir, an Orally Administered Antiviral Agent
Clinical Pharmacology & Therapeutics20253 citations13 referencesContributes 0.107
1′-Cyanocytidine-5′-isobutyryl is a potent SARS-CoV-2 inhibitor in culture and infected Syrian hamsters
Science Advances20255 citations45 referencesContributes 0.040
Emerging Strategies and Progress in the Medical Management of Marburg Virus Disease
Pathogens20259 citations95 referencesContributes 0.024

Authors (32)

Fernando R. Moreira ORCID,Nicholas Catanzaro ORCID,Meghan V. Diefenbacher ORCID,Mark R. Zweigart ORCID,Kendra L. Gully ORCID

Live enrichment

PubMed:38776389 PMC:PMC11333937 OpenAlex:https://openalex.org/W4398197771

NIAID NIH HHS

Grant: R01 AI132178

NIAID NIH HHS

Grant: U19 AI171292

FWCI

6.58

Citation Percentile

1.0%

Citation Trend

2024

2025

2026

green

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC11333937/pdf/nihms-2013155.pdf

publisherhttps://www.science.org/doi/pdf/10.1126/scitranslmed.adj4504

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/11333937

journalhttps://doi.org/10.1126/scitranslmed.adj4504

Fields of Study

SARS-CoV-2 and COVID-19 ResearchViral gastroenteritis research and epidemiologyCOVID-19 Clinical Research StudiesAnimalsSARS-CoV-2ProdrugsAntiviral AgentsHumansMiceAdministration, OralChlorocebus aethiopsVero CellsCOVID-19 Drug TreatmentCOVID-19Virus ReplicationNucleosidesFemaleDisease Models, AnimalSARS-CoV-2 variants

MeSH Terms

COVID-19SARS-CoV-2COVID-19 Drug TreatmentAdministration, OralAnimalsAntiviral AgentsChlorocebus aethiopsDisease Models, AnimalFemaleHumansNucleosidesProdrugsVero CellsVirus ReplicationCoronavirus InfectionsMice

Keywords

VirologyCoronavirusCoronaviridaeMiddle East respiratory syndromeMiddle East respiratory syndrome coronavirusAntiviral drugVirusFavipiravirBiologyMedicineIn vivoImmunologyCoronavirus disease 2019 (COVID-19)DiseaseInfectious disease (medical specialty)

Sustainable Development Goals

SDG 0: Good health and well-being