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Inhibition of heme-thiolate monooxygenase CYP1B1 prevents hepatic stellate cell activation and liver fibrosis by accumulating trehalose

Science Translational Medicine(2024)10.1126/scitranslmed.adk8446Source: DataRank Database

Inhibition of heme-thiolate monooxygenase CYP1B1 prevents hepatic stellate cell activation and liver fibrosis by accumulating trehalose is a research paper published in Science Translational Medicine (2024). On theSindex it has a DataRank of 0. It has been cited 18 times.

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0DataRank · unranked

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Open Access18 citations

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Enrichment:Funding (6 grants)Impact (FWCI 4.30)OA: greenTopics (40)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (26)

Jong‐Won Kim ORCID,Junjie Zhu ORCID,Sihan Li ORCID,Jiong Yan ORCID,Qing Liu ORCID

Live enrichment

PubMed:39321267 PMC:PMC12084873 OpenAlex:https://openalex.org/W4402826022

NIDDK NIH HHS

Grant: P30 DK120531

NIGMS NIH HHS

Grant: R01 GM111772

NIEHS NIH HHS

Grant: R35 ES030429

NIH HHS

Grant: S10 OD030254

NIDDK NIH HHS

Grant: R01 DK135538

NIDDK NIH HHS

Grant: R01 DK143511

FWCI

4.30

Citation Percentile

1.0%

Citation Trend

2025

2026

green

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC12084873/pdf/nihms-2076973.pdf

publisherhttps://www.science.org/doi/pdf/10.1126/scitranslmed.adk8446

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC12084873/

journalhttps://doi.org/10.1126/scitranslmed.adk8446

Fields of Study

Liver physiology and pathologyLiver Disease Diagnosis and TreatmentLiver Disease and TransplantationAnimalsFemaleHumansMaleMiceAutophagyCytochrome P-450 CYP1B1Hepatic Stellate CellsLiver CirrhosisMice, Inbred C57BLTrehalose

MeSH Terms

AnimalsAutophagyFemaleHumansLiver CirrhosisMaleMice, Inbred C57BLTrehaloseMiceHepatic Stellate CellsCytochrome P-450 CYP1B1

Keywords

TrehaloseHepatic stellate cellCYP1B1BiochemistryIn vivoThioacetamidePharmacologyHMOX1BiologyChemistryHeme oxygenaseCytochrome P450HemeEnzymeEndocrinology

Sustainable Development Goals

SDG 0: Good health and well-being

Inhibition of heme-thiolate monooxygenase CYP1B1 prevents hepatic stellate cell activation and liver fibrosis by accumulating trehalose

FAIR Checklist

Authors (26)

Funding (6 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)