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Selective abrogation of S6K2 identifies lipid homeostasis as a survival vulnerability in MAPK inhibitor–resistant NRAS -mutant melanoma

Science Translational Medicine(2025)10.1126/scitranslmed.adp8913Source: DataRank Database

Selective abrogation of S6K2 identifies lipid homeostasis as a survival vulnerability in MAPK inhibitor–resistant NRAS -mutant melanoma is a research paper published in Science Translational Medicine (2025). On theSindex it has a DataRank of 0.292. It has been cited 6 times.

N/A

0.292DataRank · unranked

Scored on demand from live citation data

Open Access6 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (10 grants)Impact (FWCI 2.31)OA: greenTopics (53)IDs (PubMed, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 100%Citation Network 0%

Base Score Contribution

0.292

From this paper's citation signal

Citation Network Contribution

Citation network not refreshed for this result

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Authors (17)

Adam N. Guterres ORCID,Hsin-Yi Chen ORCID,Delaine M. Zundell,Segundo W Del Aguila ORCID,Patricia Reyes-Uribe

Live enrichment

PubMed:39908352 OpenAlex:https://openalex.org/W4407160128

NCI NIH HHS

Grant: R01 CA268510

NCI NIH HHS

Grant: P30 CA016672

NIH HHS

Grant: S10 OD023586

NCI NIH HHS

Grant: P30 CA010815

NCI NIH HHS

Grant: R50 CA211199

NCI NIH HHS

Grant: T32 CA009171

NCI NIH HHS

Grant: U54 CA224070

NIGMS NIH HHS

Grant: T32 GM008275

NCI NIH HHS

Grant: P01 CA114046

NCI NIH HHS

Grant: P50 CA261608

FWCI

2.31

Citation Percentile

0.9%

Influential Citations

Citation Trend

2025

2026

greenLicense: https://www.science.org/content/page/science-licenses-journal-article-reuse

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC12258192/pdf/nihms-2081625.pdf

GREENhttps://pmc.ncbi.nlm.nih.gov/articles/PMC12258192/pdf/nihms-2081625.pdf

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC12258192/pdf/nihms-2081625.pdf

publisherhttps://www.science.org/doi/pdf/10.1126/scitranslmed.adp8913

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/12258192

Fields of Study

Protein Degradation and InhibitorsMelanoma and MAPK PathwaysAutophagy in Disease and TherapyMedicineBiologyMelanomaAnimalsHumansDrug Resistance, NeoplasmCell Line, TumorLipid MetabolismHomeostasisGTP PhosphohydrolasesMutationMiceProtein Kinase InhibitorsMembrane ProteinsMitogen-Activated Protein KinasesEndoplasmic Reticulum StressCell SurvivalXenograft Model Antitumor Assays

MeSH Terms

AnimalsCell SurvivalHomeostasisHumansMelanomaMembrane ProteinsMutationDrug Resistance, NeoplasmGTP PhosphohydrolasesMitogen-Activated Protein KinasesMAP Kinase Signaling SystemXenograft Model Antitumor AssaysRibosomal Protein S6 Kinases, 70-kDaCell Line, TumorProtein Kinase InhibitorsPPAR alphaLipid MetabolismMiceEndoplasmic Reticulum Stress

Keywords

Neuroblastoma RAS viral oncogene homologMAPK/ERK pathwayCell biologyCancer researchProtein kinase AKinaseCeramideSignal transductionBiologyApoptosisBiochemistryMutationKRAS

Sustainable Development Goals

SDG 0: Good health and well-being