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A genome-wide in vivo CRISPR activation screen identifies BACE1 as a therapeutic vulnerability of lung cancer brain metastasis

Science Translational Medicine(2025)10.1126/scitranslmed.adu2459Source: DataRank Database

A genome-wide in vivo CRISPR activation screen identifies BACE1 as a therapeutic vulnerability of lung cancer brain metastasis is a research paper published in Science Translational Medicine (2025). On theSindex it has a DataRank of 0.292. It has been cited 6 times, with 3 citing works in its 1-hop citation network.

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0.292DataRank · unranked

Scored on demand from live citation data

Open Access6 citations · 3 citing works in its network

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Linked data & code

doi

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (4 grants)Impact (FWCI 3.00)OA: greenTopics (44)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 100%Citation Network 0%

Base Score Contribution

0.292

From this paper's citation signal

Citation Network Contribution

From 0 citing papers with measurable signal

This paper's DataRank is currently driven only by its base citation score. None of the citing papers had measurable citation signal.

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Authors (40)

Kui Zhai ORCID,Nikoo Aghaei ORCID,Petar Miletic,Zhi Huang ORCID,Kevin R. Brown ORCID

Live enrichment

PubMed:40601773 PMC:PMC7617989 OpenAlex:https://openalex.org/W4411948336

Medical Research Council

Grant: CC2041

NIH HHS

Grant: S10 OD018205

Wellcome Trust

Grant: WT209199/Z/17/Z

NCRR NIH HHS

Grant: S10 RR031536

FWCI

3.00

Citation Percentile

0.9%

Citation Trend

2025

2026

greenLicense: cc-by

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/7617989

publisherhttps://www.science.org/doi/pdf/10.1126/scitranslmed.adu2459

journalhttps://doi.org/10.1126/scitranslmed.adu2459

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40601773

Fields of Study

Cancer Genomics and DiagnosticsLung Cancer Treatments and MutationsLung Cancer Research StudiesHumansBrain NeoplasmsLung NeoplasmsAmyloid Precursor Protein SecretasesAspartic Acid EndopeptidasesAnimalsCarcinoma, Non-Small-Cell LungCell Line, TumorClustered Regularly Interspaced Short Palindromic RepeatsMiceErbB ReceptorsCRISPR-Cas SystemsXenograft Model Antitumor AssaysGene Expression Regulation, Neoplastic

MeSH Terms

AnimalsBrain NeoplasmsCarcinoma, Non-Small-Cell LungHumansLung NeoplasmsGene Expression Regulation, NeoplasticAspartic Acid EndopeptidasesXenograft Model Antitumor AssaysCell Line, TumorMiceAmyloid Precursor Protein SecretasesClustered Regularly Interspaced Short Palindromic RepeatsCRISPR-Cas SystemsErbB Receptors

Keywords

Brain metastasisMetastasisCRISPRCancer researchIn vivoCancerLung cancerBiologyMedicineGenePathologyInternal medicineGenetics

Sustainable Development Goals

SDG 0: Good health and well-being

A genome-wide in vivo CRISPR activation screen identifies BACE1 as a therapeutic vulnerability of lung cancer brain metastasis

FAIR Checklist

DataRank Breakdown

Authors (40)

Funding (4 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)